TOM1L1

TOM1-like protein 1 is a protein that in humans is encoded by the TOM1L1 gene.[5][6][7][8]

TOM1L1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3RRU
Identifiers
Aliases	TOM1L1, OK/KNS-CL.3, SRCASM, target of myb1 like 1 membrane trafficking protein
External IDs	OMIM: 604701 MGI: 1919193 HomoloGene: 38055 GeneCards: TOM1L1
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q22 Start 54,899,387 bp[1] End 54,961,956 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 D|11 55.47 cM Start 90,643,465 bp[2] End 90,688,366 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • SH3 domain binding • clathrin binding • protein kinase activator activity • ubiquitin binding • GO:0001948 protein binding • protein kinase binding Cellular component • cytoplasm • cytosol • endosome • Golgi apparatus • membrane • intracellular • Golgi stack • lysosome • endosome membrane • extracellular exosome Biological process • regulation of DNA biosynthetic process • negative regulation of mitotic nuclear division • positive regulation of protein autophosphorylation • protein transport • ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway • intracellular protein transport • activation of protein kinase activity • signal transduction • transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10040	71943
Ensembl	ENSG00000141198	ENSMUSG00000020541
UniProt	O75674	Q923U0
RefSeq (mRNA)	NM_005486 NM_001321173 NM_001321174 NM_001321175 NM_001321176	NM_028011 NM_001357543 NM_001357544 NM_001357547
RefSeq (protein)	NP_001308102 NP_001308103 NP_001308104 NP_001308105 NP_005477	NP_082287 NP_001344472 NP_001344473 NP_001344476
Location (UCSC)	Chr 17: 54.9 – 54.96 Mb	Chr 11: 90.64 – 90.69 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000141198 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000020541 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Seroussi E, Kedra D, Kost-Alimova M, Sandberg-Nordqvist AC, Fransson I, Jacobs JF, Fu Y, Pan HQ, Roe BA, Imreh S, Dumanski JP (Aug 1999). "TOM1 genes map to human chromosome 22q13.1 and mouse chromosome 8C1 and encode proteins similar to the endosomal proteins HGS and STAM". Genomics. 57 (3): 380–8. doi:10.1006/geno.1998.5739. PMID 10329004.
6. Puertollano R (Mar 2005). "Interactions of TOM1L1 with the multivesicular body sorting machinery". J Biol Chem. 280 (10): 9258–64. doi:10.1074/jbc.M412481200. PMID 15611048.
7. Zhang J, Suzuki K, Hitomi T, Siraganian RP (Dec 2007). "TOM1L1 is a Lyn substrate involved in FcepsilonRI signaling in mast cells". J Biol Chem. 282 (52): 37669–77. doi:10.1074/jbc.M705168200. PMID 17977829.
8. "Entrez Gene: TOM1L1 target of myb1 (chicken)-like 1".

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Seykora JT, Mei L, Dotto GP, Stein PL (2002). "'Srcasm: a novel Src activating and signaling molecule". J. Biol. Chem. 277 (4): 2812–22. doi:10.1074/jbc.M106813200. PMID 11711534.
• Ministerial Meeting on Population of the Non-Aligned Movement (1993: Bali) (1995). "Non-aligned movement support for South-South collaboration in the field of population and family planning". Integration (Tokyo, Japan) (40): 37–42. PMID 12345679.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Katoh Y, Shiba Y, Mitsuhashi H, et al. (2004). "Tollip and Tom1 form a complex and recruit ubiquitin-conjugated proteins onto early endosomes". J. Biol. Chem. 279 (23): 24435–43. doi:10.1074/jbc.M400059200. PMID 15047686.
• Li W, Marshall C, Mei L, et al. (2005). "Srcasm modulates EGF and Src-kinase signaling in keratinocytes". J. Biol. Chem. 280 (7): 6036–46. doi:10.1074/jbc.M406546200. PMID 15579470.
• Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070. S2CID 8235923.

External links

• TOM1L1 human gene location in the UCSC Genome Browser.
• TOM1L1 human gene details in the UCSC Genome Browser.
• Overview of all the structural information available in the PDB for UniProt: O75674 (TOM1-like protein 1) at the PDBe-KB.