TOMM22

Mitochondrial import receptor subunit TOM22 homolog is a protein that in humans is encoded by the TOMM22 gene.[4][5][6]

TOMM22
Identifiers
Aliases	TOMM22, 1C9-2, MST065, MSTP065, TOM22, translocase of outer mitochondrial membrane 22
External IDs	OMIM: 607046 MGI: 2450248 HomoloGene: 10638 GeneCards: TOMM22
Gene location (Human) Chr. Chromosome 22 (human)[1] Band 22q13.1 Start 38,681,957 bp[1] End 38,685,421 bp[1]
RNA expression pattern More reference expression data
Gene ontology Molecular function • protein transmembrane transporter activity • GO:0001948 protein binding Cellular component • mitochondrial outer membrane translocase complex • integral component of membrane • mitochondrial inner membrane • mitochondrial outer membrane • integral component of mitochondrial outer membrane • membrane • mitochondrion Biological process • protein transport • protein targeting to mitochondrion • protein import into mitochondrial matrix • intracellular protein transport • protein import into mitochondrial outer membrane • macroautophagy • transport • positive regulation of apoptotic process • protein insertion into mitochondrial membrane • protein transmembrane transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	56993	223696
Ensembl	ENSG00000100216	ENSMUSG00000022427
UniProt	Q9NS69	Q9CPQ3
RefSeq (mRNA)	NM_020243	NM_172609
RefSeq (protein)	NP_064628	NP_766197
Location (UCSC)	Chr 22: 38.68 – 38.69 Mb	n/a
PubMed search	[2]	[3]
Wikidata
View/Edit Human View/Edit Mouse

The protein encoded by this gene is an integral membrane protein of the mitochondrial outer membrane. The encoded protein interacts with TOMM20 and TOMM40, and forms a complex with several other proteins to import cytosolic preproteins into the mitochondrion.[6]

See also

• Mitochondria Outer Membrane Translocase
• TOMM20
• TOMM40
• TOMM70A

References

1. GRCh38: Ensembl release 89: ENSG00000100216 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. Yano M, Hoogenraad N, Terada K, Mori M (Oct 2000). "Identification and functional analysis of human Tom22 for protein import into mitochondria". Mol Cell Biol. 20 (19): 7205–13. doi:10.1128/MCB.20.19.7205-7213.2000. PMC 86274. PMID 10982837.
5. Saeki K, Suzuki H, Tsuneoka M, Maeda M, Iwamoto R, Hasuwa H, Shida S, Takahashi T, Sakaguchi M, Endo T, Miura Y, Mekada E, Mihara K (Nov 2000). "Identification of mammalian TOM22 as a subunit of the preprotein translocase of the mitochondrial outer membrane". J Biol Chem. 275 (41): 31996–2002. doi:10.1074/jbc.M004794200. PMID 10900208.
6. "Entrez Gene: TOMM22 translocase of outer mitochondrial membrane 22 homolog (yeast)".

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Suzuki H, Okazawa Y, Komiya T, et al. (2001). "Characterization of rat TOM40, a central component of the preprotein translocase of the mitochondrial outer membrane". J. Biol. Chem. 275 (48): 37930–6. doi:10.1074/jbc.M006558200. PMID 10980201.
• Johnston AJ, Hoogenraad J, Dougan DA, et al. (2003). "Insertion and assembly of human tom7 into the preprotein translocase complex of the outer mitochondrial membrane". J. Biol. Chem. 277 (44): 42197–204. doi:10.1074/jbc.M205613200. PMID 12198123.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Yano M, Terada K, Mori M (2003). "AIP is a mitochondrial import mediator that binds to both import receptor Tom20 and preproteins". J. Cell Biol. 163 (1): 45–56. doi:10.1083/jcb.200305051. PMC 2173431. PMID 14557246.
• Yano M, Terada K, Mori M (2004). "Mitochondrial import receptors Tom20 and Tom22 have chaperone-like activity". J. Biol. Chem. 279 (11): 10808–13. doi:10.1074/jbc.M311710200. PMID 14699115.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMC 545604. PMID 15461802.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Humphries AD, Streimann IC, Stojanovski D, et al. (2005). "Dissection of the mitochondrial import and assembly pathway for human Tom40". J. Biol. Chem. 280 (12): 11535–43. doi:10.1074/jbc.M413816200. PMID 15644312.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
• Bellot G, Cartron PF, Er E, et al. (2007). "TOM22, a core component of the mitochondria outer membrane protein translocation pore, is a mitochondrial receptor for the proapoptotic protein Bax". Cell Death Differ. 14 (4): 785–94. doi:10.1038/sj.cdd.4402055. PMID 17096026.