TOMM34

Mitochondrial import receptor subunit TOM34 is a protein that in humans is encoded by the TOMM34 gene.[5][6]

TOMM34
Identifiers
Aliases	TOMM34, HTOM34P, TOM34, URCC3, translocase of outer mitochondrial membrane 34
External IDs	OMIM: 616049 MGI: 1914395 HomoloGene: 4956 GeneCards: TOMM34
Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20q13.12 Start 44,942,130 bp[1] End 44,960,397 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 H3 Start 164,053,540 bp[2] End 164,071,169 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding • heat shock protein binding Cellular component • integral component of membrane • mitochondrial outer membrane • membrane • mitochondrion • cell nucleus • nucleoplasm • cytoplasm • cytosol Biological process • protein targeting to mitochondrion Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10953	67145
Ensembl	ENSG00000025772	ENSMUSG00000018322
UniProt	Q15785	Q9CYG7
RefSeq (mRNA)	NM_006809	NM_001291155 NM_025996
RefSeq (protein)	NP_006800	NP_001278084 NP_080272
Location (UCSC)	Chr 20: 44.94 – 44.96 Mb	Chr 2: 164.05 – 164.07 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

The protein encoded by this gene is involved in the import of precursor proteins into mitochondria. The encoded protein has a chaperone-like activity, binding the mature portion of unfolded proteins and aiding their import into mitochondria. This protein, which is found in the cytoplasm and sometimes associated with the outer mitochondrial membrane, has a weak ATPase activity and contains 6 TPR repeats.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000025772 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000018322 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Nuttall SD, Hanson BJ, Mori M, Hoogenraad NJ (Oct 1997). "hTom34: a novel translocase for the import of proteins into human mitochondria". DNA Cell Biol. 16 (9): 1067–74. doi:10.1089/dna.1997.16.1067. PMID 9324309.
6. "Entrez Gene: TOMM34 translocase of outer mitochondrial membrane 34".

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Young JC, Obermann WM, Hartl FU (1998). "Specific binding of tetratricopeptide repeat proteins to the C-terminal 12-kDa domain of hsp90". J. Biol. Chem. 273 (29): 18007–10. doi:10.1074/jbc.273.29.18007. PMID 9660753.
• Chewawiwat N, Yano M, Terada K, et al. (1999). "Characterization of the novel mitochondrial protein import component, Tom34, in mammalian cells". J. Biochem. 125 (4): 721–7. doi:10.1093/oxfordjournals.jbchem.a022342. PMID 10101285.
• Fossey SC, Mychaleckyj JC, Pendleton JK, et al. (2001). "A high-resolution 6.0-megabase transcript map of the type 2 diabetes susceptibility region on human chromosome 20". Genomics. 76 (1–3): 45–57. doi:10.1006/geno.2001.6584. PMID 11549316.
• Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.
• Mukhopadhyay A, Avramova LV, Weiner H (2002). "Tom34 unlike Tom20 does not interact with the leader sequences of mitochondrial precursor proteins". Arch. Biochem. Biophys. 400 (1): 97–104. doi:10.1006/abbi.2002.2777. PMID 11913975.
• Yang CS, Weiner H (2002). "Yeast two-hybrid screening identifies binding partners of human Tom34 that have ATPase activity and form a complex with Tom34 in the cytosol". Arch. Biochem. Biophys. 400 (1): 105–10. doi:10.1006/abbi.2002.2778. PMID 11913976.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Shimokawa T, Matsushima S, Tsunoda T, et al. (2006). "Identification of TOMM34, which shows elevated expression in the majority of human colon cancers, as a novel drug target". Int. J. Oncol. 29 (2): 381–6. doi:10.3892/ijo.29.2.381. PMID 16820880.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.