TOPORS

E3 ubiquitin-protein ligase Topors is an enzyme that in humans is encoded by the TOPORS gene.[5][6][7][8]

TOPORS
Identifiers
Aliases	TOPORS, LUN, P53BP3, RP31, TP53BPL, TOP1 binding arginine/serine rich protein, TOP1 binding arginine/serine rich protein, E3 ubiquitin ligase
External IDs	OMIM: 609507 MGI: 2146189 HomoloGene: 4237 GeneCards: TOPORS
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9p21.1 Start 32,540,544 bp[1] End 32,552,586 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 A5 Start 40,259,601 bp[2] End 40,269,850 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • antigen binding • DNA binding • SUMO transferase activity • GO:1904264, GO:1904822, GO:0090622, GO:0090302 ubiquitin protein ligase activity • metal ion binding • ubiquitin-protein transferase activity • DNA topoisomerase binding • GO:0001948 protein binding • transferase activity Cellular component • ciliary basal body • PML body • nuclear speck • spindle pole • ubiquitin ligase complex • gamma-tubulin complex • photoreceptor connecting cilium • midbody • cytoplasmic dynein complex • centriole • cell nucleus • nucleoplasm Biological process • intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator • retina layer formation • ubiquitin-dependent protein catabolic process • protein polyubiquitination • negative regulation of apoptotic process • retinal cone cell development • protein monoubiquitination • photoreceptor cell outer segment organization • protein sumoylation • transcription, DNA-templated • cellular response to DNA damage stimulus • positive regulation of transcription, DNA-templated • protein K48-linked ubiquitination • regulation of cell proliferation • positive regulation of ubiquitin-protein transferase activity • retinal rod cell development • intrinsic apoptotic signaling pathway in response to DNA damage • protein localization to nucleus • maintenance of protein location in nucleus • proteasome-mediated ubiquitin-dependent protein catabolic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10210	106021
Ensembl	ENSG00000197579	ENSMUSG00000036822
UniProt	Q9NS56	Q80Z37
RefSeq (mRNA)	NM_005802 NM_001195622	NM_134097
RefSeq (protein)	NP_001182551 NP_005793	NP_598858
Location (UCSC)	Chr 9: 32.54 – 32.55 Mb	Chr 4: 40.26 – 40.27 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000197579 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000036822 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Haluska P Jr, Saleem A, Rasheed Z, Ahmed F, Su EW, Liu LF, Rubin EH (Jul 1999). "Interaction between human topoisomerase I and a novel RING finger/arginine-serine protein". Nucleic Acids Res. 27 (12): 2538–44. doi:10.1093/nar/27.12.2538. PMC 148458. PMID 10352183.
6. Rasheed ZA, Saleem A, Ravee Y, Pandolfi PP, Rubin EH (Jun 2002). "The topoisomerase I-binding RING protein, topors, is associated with promyelocytic leukemia nuclear bodies". Exp Cell Res. 277 (2): 152–60. doi:10.1006/excr.2002.5550. PMID 12083797.
7. Chakarova CF, Papaioannou MG, Khanna H, Lopez I, Waseem N, Shah A, Theis T, Friedman J, Maubaret C, Bujakowska K, Veraitch B, Abd El-Aziz MM, Prescott de Q, Parapuram SK, Bickmore WA, Munro PM, Gal A, Hamel CP, Marigo V, Ponting CP, Wissinger B, Zrenner E, Matter K, Swaroop A, Koenekoop RK, Bhattacharya SS (Oct 2007). "Mutations in TOPORS cause autosomal dominant retinitis pigmentosa with perivascular retinal pigment epithelium atrophy". Am J Hum Genet. 81 (5): 1098–103. doi:10.1086/521953. PMC 2265653. PMID 17924349.
8. "Entrez Gene: TOPORS topoisomerase I binding, arginine/serine-rich".

Further reading

• Zhou R, Wen H, Ao SZ (1999). "Identification of a novel gene encoding a p53-associated protein". Gene. 235 (1–2): 93–101. doi:10.1016/S0378-1119(99)00203-6. PMID 10415337.
• Souto-Carneiro MM, Krenn V, Hermann R, et al. (2001). "IgVH genes from different anatomical regions, with different histopathological patterns, of a rheumatoid arthritis patient suggest cyclic re-entry of mature synovial B-cells in the hypermutation process". Arthritis Res. 2 (4): 303–14. doi:10.1186/ar105. PMC 17813. PMID 11056671.
• Chu D, Kakazu N, Gorrin-Rivas MJ, et al. (2001). "Cloning and characterization of LUN, a novel ring finger protein that is highly expressed in lung and specifically binds to a palindromic sequence" (PDF). J. Biol. Chem. 276 (17): 14004–13. doi:10.1074/jbc.M010262200. PMID 11278651. S2CID 20734219.
• Weger S, Hammer E, Heilbronn R (2002). "Topors, a p53 and topoisomerase I binding protein, interacts with the adeno-associated virus (AAV-2) Rep78/68 proteins and enhances AAV-2 gene expression". J. Gen. Virol. 83 (Pt 3): 511–6. doi:10.1099/0022-1317-83-3-511. PMID 11842245.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Imabayashi H, Mori T, Gojo S, et al. (2003). "Redifferentiation of dedifferentiated chondrocytes and chondrogenesis of human bone marrow stromal cells via chondrosphere formation with expression profiling by large-scale cDNA analysis". Exp. Cell Res. 288 (1): 35–50. doi:10.1016/S0014-4827(03)00130-7. PMID 12878157.
• Weger S, Hammer E, Engstler M (2003). "The DNA topoisomerase I binding protein topors as a novel cellular target for SUMO-1 modification: characterization of domains necessary for subcellular localization and sumolation". Exp. Cell Res. 290 (1): 13–27. doi:10.1016/S0014-4827(03)00292-1. PMID 14516784.
• Saleem A, Dutta J, Malegaonkar D, et al. (2004). "The topoisomerase I- and p53-binding protein topors is differentially expressed in normal and malignant human tissues and may function as a tumor suppressor". Oncogene. 23 (31): 5293–300. doi:10.1038/sj.onc.1207700. PMID 15107820.
• Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.
• Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
• Rajendra R, Malegaonkar D, Pungaliya P, et al. (2004). "Topors functions as an E3 ubiquitin ligase with specific E2 enzymes and ubiquitinates p53". J. Biol. Chem. 279 (35): 36440–4. doi:10.1074/jbc.C400300200. PMID 15247280.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Oyanagi H, Takenaka K, Ishikawa S, et al. (2005). "Expression of LUN gene that encodes a novel RING finger protein is correlated with development and progression of non-small cell lung cancer". Lung Cancer. 46 (1): 21–8. doi:10.1016/j.lungcan.2004.03.009. hdl:2433/145282. PMID 15364129.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Flatten K, Dai NT, Vroman BT, et al. (2005). "The role of checkpoint kinase 1 in sensitivity to topoisomerase I poisons". J. Biol. Chem. 280 (14): 14349–55. doi:10.1074/jbc.M411890200. PMID 15699047.
• Lin L, Ozaki T, Takada Y, et al. (2005). "topors, a p53 and topoisomerase I-binding RING finger protein, is a coactivator of p53 in growth suppression induced by DNA damage". Oncogene. 24 (21): 3385–96. doi:10.1038/sj.onc.1208554. PMID 15735665.
• Weger S, Hammer E, Heilbronn R (2005). "Topors acts as a SUMO-1 E3 ligase for p53 in vitro and in vivo". FEBS Lett. 579 (22): 5007–12. doi:10.1016/j.febslet.2005.07.088. PMID 16122737. S2CID 40285751.
• Papaioannou M, Chakarova CF, Prescott DC, et al. (2006). "A new locus (RP31) for autosomal dominant retinitis pigmentosa maps to chromosome 9p". Hum. Genet. 118 (3–4): 501–3. doi:10.1007/s00439-005-0063-3. PMID 16189705. S2CID 28018465.

External links

• TOPORS human gene location in the UCSC Genome Browser.
• TOPORS human gene details in the UCSC Genome Browser.