TRANK1

Tetratricopeptide repeat and ankyrin repeat containing 1 is a protein that in humans is encoded by the TRANK1 gene.[5]

TRANK1
Identifiers
Aliases	TRANK1, LBA1, tetratricopeptide repeat and ankyrin repeat containing 1
External IDs	MGI: 1341834 HomoloGene: 45845 GeneCards: TRANK1
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3p22.2 Start 36,826,820 bp[1] End 36,945,098 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 F3 Start 111,311,739 bp[2] End 111,395,775 bp[2]
Orthologs
Species	Human	Mouse
Entrez	9881	320429
Ensembl	ENSG00000168016	ENSMUSG00000062296
UniProt	O15050	Q8BV79
RefSeq (mRNA)	NM_014831 NM_001329998	NM_001164659
RefSeq (protein)	NP_001316927 NP_055646	NP_001158131
Location (UCSC)	Chr 3: 36.83 – 36.95 Mb	Chr 9: 111.31 – 111.4 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Disease Linkage

Through a Genome-wide association study, TRANK1 has been relationed with the Bipolar disorder.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000168016 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000062296 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Tetratricopeptide repeat and ankyrin repeat containing 1".
6. Mühleisen TW, Leber M, Schulze TG, Strohmaier J, Degenhardt F, Treutlein J, et al. (March 2014). "Genome-wide association study reveals two new risk loci for bipolar disorder". Nature Communications. 5: 3339. Bibcode:2014NatCo...5.3339M. doi:10.1038/ncomms4339. PMID 24618891.

Further reading

• Goes FS, Hamshere ML, Seifuddin F, Pirooznia M, Belmonte-Mahon P, Breuer R, et al. (October 2012). "Genome-wide association of mood-incongruent psychotic bipolar disorder". Translational Psychiatry. 2 (10): e180. doi:10.1038/tp.2012.106. PMC 3565814. PMID 23092984.
• Chen DT, Jiang X, Akula N, Shugart YY, Wendland JR, Steele CJ, et al. (February 2013). "Genome-wide association study meta-analysis of European and Asian-ancestry samples identifies three novel loci associated with bipolar disorder". Molecular Psychiatry. 18 (2): 195–205. doi:10.1038/mp.2011.157. PMID 22182935.