TRAT1

T-cell receptor-associated transmembrane adapter 1 is a protein that in humans is encoded by the TRAT1 gene.[5][6][7]

TRAT1
Identifiers
Aliases	TRAT1, TCRIM, TRIM, HSPC062, pp29/30, T cell receptor associated transmembrane adaptor 1, T-cell receptor associated transmembrane adaptor 1
External IDs	OMIM: 604962 MGI: 1924897 HomoloGene: 41130 GeneCards: TRAT1
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3q13.13 Start 108,822,770 bp[1] End 108,855,005 bp[1]
Gene location (Mouse) Chr. Chromosome 16 (mouse)[2] Band 16|16 B5 Start 48,730,774 bp[2] End 48,772,021 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • transmembrane receptor protein tyrosine kinase adaptor activity • phosphatidylinositol-4,5-bisphosphate 3-kinase activity Cellular component • integral component of membrane • membrane • cell membrane • integral component of plasma membrane • T cell receptor complex Biological process • positive regulation of calcium-mediated signaling • adaptive immune response • immune system process • positive regulation of T cell receptor signaling pathway • negative regulation of transport • cellular defense response • T cell receptor signaling pathway • negative regulation of receptor recycling • signal transduction • phosphatidylinositol phosphorylation • transmembrane receptor protein tyrosine kinase signaling pathway • positive regulation of protein kinase B signaling Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	50852	77647
Ensembl	ENSG00000163519	ENSMUSG00000030775
UniProt	Q6PIZ9	Q3UU67
RefSeq (mRNA)	NM_016388 NM_001317747	NM_198297
RefSeq (protein)	NP_001304676 NP_057472	NP_938039
Location (UCSC)	Chr 3: 108.82 – 108.86 Mb	Chr 16: 48.73 – 48.77 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000163519 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000030775 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Hubener C, Mincheva A, Lichter P, Schraven B, Bruyns E (Mar 2000). "Genomic organization and chromosomal localization of the human gene encoding the T-cell receptor-interacting molecule (TRIM)". Immunogenetics. 51 (2): 154–8. doi:10.1007/s002510050024. PMID 10663578. S2CID 43325566.
6. Bruyns E, Marie-Cardine A, Kirchgessner H, Sagolla K, Shevchenko A, Mann M, Autschbach F, Bensussan A, Meuer S, Schraven B (Sep 1998). "T cell receptor (TCR) interacting molecule (TRIM), a novel disulfide-linked dimer associated with the TCR-CD3-zeta complex, recruits intracellular signaling proteins to the plasma membrane". J Exp Med. 188 (3): 561–75. doi:10.1084/jem.188.3.561. PMC 2212462. PMID 9687533.
7. "Entrez Gene: TRAT1 T cell receptor associated transmembrane adaptor 1".

Further reading

• Zhang W, Samelson LE (2000). "The role of membrane-associated adaptors in T cell receptor signalling". Semin. Immunol. 12 (1): 35–41. doi:10.1006/smim.2000.0205. PMID 10723796.
• Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
• Kirchgessner H, Dietrich J, Scherer J, et al. (2001). "The transmembrane adaptor protein TRIM regulates T cell receptor (TCR) expression and TCR-mediated signaling via an association with the TCR zeta chain". J. Exp. Med. 193 (11): 1269–84. doi:10.1084/jem.193.11.1269. PMC 2193385. PMID 11390434.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Tedoldi S, Paterson JC, Hansmann ML, et al. (2006). "Transmembrane adaptor molecules: a new category of lymphoid-cell markers". Blood. 107 (1): 213–21. doi:10.1182/blood-2005-06-2273. PMID 16160011.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.