TRIM38

Tripartite motif containing 38 is a protein that in humans is encoded by the TRIM38 gene. [5]

TRIM38
Identifiers
Aliases	TRIM38, RNF15, RORET, tripartite motif containing 38
External IDs	MGI: 2684869 HomoloGene: 48427 GeneCards: TRIM38
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p22.2 Start 25,962,802 bp[1] End 25,991,231 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13|13 A3.1 Start 23,769,913 bp[2] End 23,791,528 bp[2]
Gene ontology Molecular function • zinc ion binding • signal transducer activity • metal ion binding • GO:0001948 protein binding • transferase activity Cellular component • cytosol • intracellular Biological process • immune system process • interferon-gamma-mediated signaling pathway • positive regulation of sequence-specific DNA binding transcription factor activity • positive regulation of NF-kappaB transcription factor activity • protein ubiquitination • positive regulation of I-kappaB kinase/NF-kappaB signaling • innate immune system Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10475	214158
Ensembl	ENSG00000112343	ENSMUSG00000064140
UniProt	O00635	Q5SZ99
RefSeq (mRNA)	NM_006355	NM_001029935
RefSeq (protein)	NP_006346	NP_001025106
Location (UCSC)	Chr 6: 25.96 – 25.99 Mb	Chr 13: 23.77 – 23.79 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene encodes a member of the tripartite motif (TRIM) family. The encoded protein contains a RING-type zinc finger, B box-type zinc finger and SPRY domain. The function of this protein has not been identified. A pseudogene of this gene is located on the long arm of chromosome 4. [provided by RefSeq, Jul 2012].

References

1. GRCh38: Ensembl release 89: ENSG00000112343 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000064140 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Tripartite motif containing 38". Retrieved 2018-03-21.

Further reading

• Liu X, Lei X, Zhou Z, Sun Z, Xue Q, Wang J, Hung T (February 2011). "Enterovirus 71 induces degradation of TRIM38, a potential E3 ubiquitin ligase". Virol. J. 8: 61. doi:10.1186/1743-422X-8-61. PMC 3048563. PMID 21306652.
• Liu XL, Lei XB, Wang JW, Hong T (February 2011). "[Identification A novel protein TRIM38 that activate NF-kappaB signaling pathways]". Zhonghua Shi Yan He Lin Chuang Bing du Xue Za Zhi (in Chinese). 25 (1): 60–2. PMID 21789858.
• Xue Q, Zhou Z, Lei X, Liu X, He B, Wang J, Hung T (2012). "TRIM38 negatively regulates TLR3-mediated IFN-β signaling by targeting TRIF for degradation". PLOS ONE. 7 (10): e46825. doi:10.1371/journal.pone.0046825. PMC 3466175. PMID 23056470.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.