TRIM6

Tripartite motif-containing protein 6 is a protein that in humans is encoded by the TRIM6 gene.[5][6]

TRIM6
Identifiers
Aliases	TRIM6, RNF89, tripartite motif containing 6
External IDs	OMIM: 607564 MGI: 2137352 HomoloGene: 14381 GeneCards: TRIM6
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11p15.4 Start 5,596,109 bp[1] End 5,612,958 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7 E3|7 55.55 cM Start 104,218,793 bp[2] End 104,235,152 bp[2]
Gene ontology Molecular function • protein binding, bridging • protein tyrosine kinase binding • GO:1904264, GO:1904822, GO:0090622, GO:0090302 ubiquitin protein ligase activity • zinc ion binding • transcription factor binding • metal ion binding • GO:0001948 protein binding • protein kinase binding • transferase activity Cellular component • cytoplasm • cytosol • intracellular • cell nucleus Biological process • positive regulation of transcription regulatory region DNA binding • cellular response to virus • positive regulation of type I interferon-mediated signaling pathway • regulation of NIK/NF-kappaB signaling • free ubiquitin chain polymerization • cellular response to interferon-beta • protein trimerization • protein polyubiquitination • negative regulation of gene expression • positive regulation of peptidyl-serine phosphorylation • negative regulation of stem cell differentiation • response to lipopolysaccharide • negative regulation of viral genome replication • positive regulation of gene expression • positive regulation of peptidyl-threonine phosphorylation • protein ubiquitination • negative regulation of transcription, DNA-templated • positive regulation of defense response to virus by host • GO:0022415 viral process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	117854	94088
Ensembl	ENSG00000121236	ENSMUSG00000072244
UniProt	Q9C030	Q8BGE7
RefSeq (mRNA)	NM_058166 NM_001003818 NM_001198644 NM_001198645	NM_001013616
RefSeq (protein)	NP_001003818 NP_001185573 NP_001185574 NP_477514	NP_001013637
Location (UCSC)	Chr 11: 5.6 – 5.61 Mb	Chr 7: 104.22 – 104.24 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region.

The protein localizes to the nucleus, but its specific function has not been identified. This gene is mapped to chromosome 11p15, where it resides within a TRIM gene cluster. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. A read-through transcript transcribed from this gene and TRIM34 has been observed.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000121236 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000072244 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Reymond A, Meroni G, Fantozzi A, Merla G, Cairo S, Luzi L, Riganelli D, Zanaria E, Messali S, Cainarca S, Guffanti A, Minucci S, Pelicci PG, Ballabio A (May 2001). "The tripartite motif family identifies cell compartments". EMBO J. 20 (9): 2140–51. doi:10.1093/emboj/20.9.2140. PMC 125245. PMID 11331580.
6. "Entrez Gene: TRIM6 tripartite motif-containing 6".

Further reading

• Li X, Gold B, O'hUigin C, et al. (2007). "Unique features of TRIM5alpha among closely related human TRIM family members". Virology. 360 (2): 419–33. doi:10.1016/j.virol.2006.10.035. PMID 17156811.
• Zhang F, Hatziioannou T, Perez-Caballero D, et al. (2006). "Antiretroviral potential of human tripartite motif-5 and related proteins". Virology. 353 (2): 396–409. doi:10.1016/j.virol.2006.05.035. PMID 16828831.
• Li X, Li Y, Stremlau M, et al. (2006). "Functional replacement of the RING, B-box 2, and coiled-coil domains of tripartite motif 5alpha (TRIM5alpha) by heterologous TRIM domains". J. Virol. 80 (13): 6198–206. doi:10.1128/JVI.00283-06. PMC 1488960. PMID 16775307.
• Woo JS, Imm JH, Min CK, et al. (2006). "Structural and functional insights into the B30.2/SPRY domain". EMBO J. 25 (6): 1353–63. doi:10.1038/sj.emboj.7600994. PMC 1422157. PMID 16498413.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Orimo A, Tominaga N, Yoshimura K, et al. (2001). "Molecular cloning of ring finger protein 21 (RNF21)/interferon-responsive finger protein (ifp1), which possesses two RING-B box-coiled coil domains in tandem". Genomics. 69 (1): 143–9. doi:10.1006/geno.2000.6318. PMID 11013086.