TRIM69

Tripartite motif containing 69 is a protein that in humans is encoded by the TRIM69 gene. [5]

TRIM69
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4NQJ
Identifiers
Aliases	TRIM69, HSD-34, HSD34, RNF36, Trif, tripartite motif containing 69
External IDs	OMIM: 616017 MGI: 1918178 HomoloGene: 18827 GeneCards: TRIM69
Gene location (Human) Chr. Chromosome 15 (human)[1] Band 15q21.1 Start 44,728,988 bp[1] End 44,767,829 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 E5 Start 122,160,700 bp[2] End 122,179,027 bp[2]
Gene ontology Molecular function • GO:0001948 protein binding • metal ion binding • ubiquitin-protein transferase activity • transferase activity Cellular component • cytoplasm • nuclear speck • cell nucleus • cytosol Biological process • protein ubiquitination • apoptotic process • protein polyubiquitination Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	140691	70928
Ensembl	ENSG00000278211 ENSG00000185880	ENSMUSG00000033368
UniProt	Q86WT6	Q80X56
RefSeq (mRNA)	NM_182985 NM_001301144 NM_001301145 NM_001301146 NM_080745	NM_080510 NM_001379369
RefSeq (protein)	NP_001288073 NP_001288074 NP_001288075 NP_542783 NP_892030	NP_536771 NP_001366298
Location (UCSC)	Chr 15: 44.73 – 44.77 Mb	Chr 2: 122.16 – 122.18 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene encodes a member of the RING-B-box-coiled-coil (RBCC) family and encodes a protein with an N-terminal RING finger motif, a PRY domain and a C-terminal SPRY domain. The mouse ortholog of this gene is specifically expressed in germ cells at the round spermatid stages during spermatogenesis and, when overexpressed, induces apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been described.

References

1. ENSG00000185880 GRCh38: Ensembl release 89: ENSG00000278211, ENSG00000185880 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000033368 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Tripartite motif containing 69". Retrieved 2016-02-16.

External links

• PDBe-KB provides an overview of all the structure information available in the PDB for Human E3 ubiquitin-protein ligase TRIM69

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.