TRIP12

Probable E3 ubiquitin-protein ligase TRIP12 is an enzyme that in humans is encoded by the TRIP12 gene.[4][5]

TRIP12
Identifiers
Aliases	TRIP12, TRIP-12, ULF, thyroid hormone receptor interactor 12
External IDs	OMIM: 604506 MGI: 1309481 HomoloGene: 44226 GeneCards: TRIP12
Gene location (Mouse) Chr. Chromosome 1 (mouse)[1] Band 1|1 C5 Start 84,721,189 bp[1] End 84,840,516 bp[1]
RNA expression pattern More reference expression data
Gene ontology Molecular function • thyroid hormone receptor binding • GO:0001948 protein binding • ubiquitin-protein transferase activity • transferase activity • GO:1904264, GO:1904822, GO:0090622, GO:0090302 ubiquitin protein ligase activity Cellular component • cell nucleus • nucleoplasm • cytosol • nuclear speck • cytoplasm Biological process • negative regulation of double-strand break repair • negative regulation of histone H2A K63-linked ubiquitination • DNA repair • protein ubiquitination • embryo development • cellular response to DNA damage stimulus • protein polyubiquitination • ubiquitin-dependent protein catabolic process • regulation of embryonic development Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	9320	14897
Ensembl	ENSG00000153827	ENSMUSG00000026219
UniProt	Q14669	G5E870
RefSeq (mRNA)	NM_001284214 NM_001284215 NM_001284216 NM_004238	NM_133975
RefSeq (protein)	NP_001271143 NP_001271144 NP_001271145 NP_004229 NP_001335244 NP_001335245 NP_001335246 NP_001335247 NP_001335248 NP_001335249 NP_001335250 NP_001335251 NP_001335252 NP_001335253 NP_001335254 NP_001335255 NP_001335256 NP_001335257 NP_001335258 NP_001335259 NP_001335260 NP_001335261 NP_001335262 NP_001335263 NP_001335264 NP_001335265	NP_598736
Location (UCSC)	n/a	Chr 1: 84.72 – 84.84 Mb
PubMed search	[2]	[3]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

TRIP12 has been shown to interact with APPBP1.[6]

References

1. GRCm38: Ensembl release 89: ENSMUSG00000026219 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. Lee JW, Choi HS, Gyuris J, Brent R, Moore DD (Jul 1995). "Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor". Mol Endocrinol. 9 (2): 243–54. doi:10.1210/me.9.2.243. PMID 7776974.
5. "Entrez Gene: TRIP12 thyroid hormone receptor interactor 12".
6. Park, Yoon; Yoon Sungjoo Kim; Yoon Jong-Bok (Sep 2008). "TRIP12 functions as an E3 ubiquitin ligase of APP-BP1". Biochem. Biophys. Res. Commun. United States. 374 (2): 294–8. doi:10.1016/j.bbrc.2008.07.019. PMID 18627766.

Further reading

• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
• Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Nakayama M, Kikuno R, Ohara O (2003). "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs". Genome Res. 12 (11): 1773–84. doi:10.1101/gr.406902. PMC 187542. PMID 12421765.
• Nomura N, Nagase T, Miyajima N, et al. (1995). "Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 1 (5): 223–9. doi:10.1093/dnares/1.5.223. PMID 7584044.