TRIP4

Activating signal cointegrator 1 is a protein that in humans is encoded by the TRIP4 gene.[5][6]

TRIP4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2E5O
Identifiers
Aliases	TRIP4, ASC-1, ASC1, HsT17391, ZC2HC5, SMABF1, thyroid hormone receptor interactor 4, MDCDC
External IDs	OMIM: 604501 MGI: 1928469 HomoloGene: 9426 GeneCards: TRIP4
Gene location (Human) Chr. Chromosome 15 (human)[1] Band 15q22.31 Start 64,387,748 bp[1] End 64,455,303 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 C Start 65,828,930 bp[2] End 65,908,794 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • protease binding • GO:0001105 transcription coactivator activity • zinc ion binding • estrogen receptor binding • GO:0001948 protein binding • histone acetyltransferase binding • ligand-dependent nuclear receptor binding • ubiquitin-like protein ligase binding • metal ion binding • protein kinase binding Cellular component • cytoplasm • cytosol • cytoskeleton • cell nucleus • nucleoplasm • microtubule organizing center • neuromuscular junction • nuclear body • activating signal cointegrator 1 complex • centrosome • macromolecular complex Biological process • positive regulation of transcription, DNA-templated • toxin transport • intracellular estrogen receptor signaling pathway • transcription, DNA-templated • regulation of transcription, DNA-templated • regulation of myoblast differentiation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	9325	56404
Ensembl	ENSG00000103671	ENSMUSG00000032386
UniProt	Q15650	Q9QXN3
RefSeq (mRNA)	NM_016213 NM_001321924	NM_001170907 NM_019797 NM_001357872
RefSeq (protein)	NP_001308853 NP_057297	NP_001164378 NP_062771 NP_001344801
Location (UCSC)	Chr 15: 64.39 – 64.46 Mb	Chr 9: 65.83 – 65.91 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

TRIP4 has been shown to interact with Nuclear receptor coactivator 1.[7]

References

1. GRCh38: Ensembl release 89: ENSG00000103671 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000032386 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Lee JW, Choi HS, Gyuris J, Brent R, Moore DD (July 1995). "Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor". Mol Endocrinol. 9 (2): 243–54. doi:10.1210/me.9.2.243. PMID 7776974.
6. "Entrez Gene: TRIP4 thyroid hormone receptor interactor 4".
7. Kim HJ, Yi JY, Sung HS, Moore DD, Jhun BH, Lee YC, Lee JW (1999). "Activating signal cointegrator 1, a novel transcription coactivator of nuclear receptors, and its cytosolic localization under conditions of serum deprivation". Mol. Cell. Biol. 19 (9): 6323–32. doi:10.1128/mcb.19.9.6323. PMC 84603. PMID 10454579.

Further reading

• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Jung DJ, Sung HS, Goo YW, et al. (2002). "Novel transcription coactivator complex containing activating signal cointegrator 1". Mol. Cell. Biol. 22 (14): 5203–11. doi:10.1128/MCB.22.14.5203-5211.2002. PMC 139772. PMID 12077347.
• Lee SK, Anzick SL, Choi JE, et al. (1999). "A nuclear factor, ASC-2, as a cancer-amplified transcriptional coactivator essential for ligand-dependent transactivation by nuclear receptors in vivo". J. Biol. Chem. 274 (48): 34283–93. doi:10.1074/jbc.274.48.34283. PMID 10567404.
• Kim HJ, Yi JY, Sung HS, et al. (1999). "Activating signal cointegrator 1, a novel transcription coactivator of nuclear receptors, and its cytosolic localization under conditions of serum deprivation". Mol. Cell. Biol. 19 (9): 6323–32. doi:10.1128/mcb.19.9.6323. PMC 84603. PMID 10454579.