TRMT12

tRNA wybutosine-synthesizing protein 2 homolog is a protein that in humans is encoded by the TRMT12 gene.[5][6][7]

TRMT12
Identifiers
Aliases	TRMT12, TRM12, TYW2, tRNA methyltransferase 12 homolog
External IDs	OMIM: 611244 MGI: 1915510 HomoloGene: 32379 GeneCards: TRMT12
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8q24.13 Start 124,450,820 bp[1] End 124,462,150 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15|15 D1 Start 58,872,674 bp[2] End 58,877,127 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding • transferase activity • tRNA 4-demethylwyosine alpha-amino-alpha-carboxypropyltransferase activity • tRNA methyltransferase activity Cellular component • cytoplasm Biological process • tRNA processing • tRNA methylation • wybutosine biosynthetic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	55039	68260
Ensembl	ENSG00000183665	ENSMUSG00000037085
UniProt	Q53H54	Q8BG71
RefSeq (mRNA)	NM_017956	NM_026642
RefSeq (protein)	NP_060426	NP_080918
Location (UCSC)	Chr 8: 124.45 – 124.46 Mb	Chr 15: 58.87 – 58.88 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000183665 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000037085 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Kalhor HR, Penjwini M, Clarke S (Jul 2005). "A novel methyltransferase required for the formation of the hypermodified nucleoside wybutosine in eucaryotic tRNA". Biochem Biophys Res Commun. 334 (2): 433–40. doi:10.1016/j.bbrc.2005.06.111. PMID 16005430.
6. Noma A, Suzuki T (Dec 2006). "Ribonucleome analysis identified enzyme genes responsible for wybutosine synthesis". Nucleic Acids Symp Ser (Oxf). 50 (50): 65–6. doi:10.1093/nass/nrl032. PMID 17150819.
7. "Entrez Gene: TRMT12 tRNA methyltransferase 12 homolog (S. cerevisiae)".

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Rodriguez V, Chen Y, Elkahloun A, et al. (2007). "Chromosome 8 BAC array comparative genomic hybridization and expression analysis identify amplification and overexpression of TRMT12 in breast cancer". Genes Chromosomes Cancer. 46 (7): 694–707. doi:10.1002/gcc.20454. PMID 17440925. S2CID 36237771.