TRMU

Mitochondrial tRNA-specific 2-thiouridylase 1 is an enzyme that in humans is encoded by the TRMU gene.[5][6]

TRMU
Identifiers
Aliases	TRMU, MTO2, MTU1, TRMT, TRMT1, TRNT1, LCAL3, tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase
External IDs	OMIM: 610230 MGI: 1919276 HomoloGene: 5589 GeneCards: TRMU
Gene location (Human) Chr. Chromosome 22 (human)[1] Band 22q13.31 Start 46,330,875 bp[1] End 46,357,340 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15|15 E2 Start 85,879,312 bp[2] End 85,897,394 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • RNA binding • transferase activity • tRNA binding • nucleotide binding • sulfurtransferase activity • ATP binding • methyltransferase activity Cellular component • mitochondrion • nucleoplasm Biological process • tRNA wobble position uridine thiolation • mitochondrial tRNA thio-modification • tRNA processing • methylation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	55687	72026
Ensembl	ENSG00000100416	ENSMUSG00000022386
UniProt	O75648 Q2PPL5	Q9DAT5
RefSeq (mRNA)	NM_001008569 NM_001008571 NM_001282782 NM_001282783 NM_001282784 NM_001282785 NM_018006	NM_028063
RefSeq (protein)	NP_001269711 NP_001269712 NP_001269713 NP_001269714 NP_060476 NP_001269711.1	NP_082339
Location (UCSC)	Chr 22: 46.33 – 46.36 Mb	Chr 15: 85.88 – 85.9 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

This gene is a member of the trmU family. It encodes a mitochondria-specific tRNA-modifying enzyme that is required for the 2-thio modification of 5-taurinomethyl-2-thiouridine tRNA-Lys on the wobble position of the anticodon.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000100416 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000022386 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Yan Q, Guan MX (Jan 2004). "Identification and characterization of mouse TRMU gene encoding the mitochondrial 5-methylaminomethyl-2-thiouridylate-methyltransferase". Biochim Biophys Acta. 1676 (2): 119–26. doi:10.1016/j.bbaexp.2003.11.010. PMID 14746906.
6. "Entrez Gene: TRMU tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase".

Further reading

• Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMC 545604. PMID 15461802.
• Umeda N, Suzuki T, Yukawa M, et al. (2005). "Mitochondria-specific RNA-modifying enzymes responsible for the biosynthesis of the wobble base in mitochondrial tRNAs. Implications for the molecular pathogenesis of human mitochondrial diseases". J. Biol. Chem. 280 (2): 1613–24. doi:10.1074/jbc.M409306200. PMID 15509579.
• Yan Q, Li X, Faye G, Guan MX (2005). "Mutations in MTO2 Related to tRNA Modification Impair Mitochondrial Gene Expression and Protein Synthesis in the Presence of a Paromomycin Resistance Mutation in Mitochondrial 15 S rRNA". J. Biol. Chem. 280 (32): 29151–7. doi:10.1074/jbc.M504247200. PMC 2905382. PMID 15944150.
• Oh JH, Yang JO, Hahn Y, et al. (2006). "Transcriptome analysis of human gastric cancer". Mamm. Genome. 16 (12): 942–54. doi:10.1007/s00335-005-0075-2. PMID 16341674.
• Yan Q, Bykhovskaya Y, Li R, et al. (2006). "Human TRMU encoding the mitochondrial 5-methylaminomethyl-2-thiouridylate-methyltransferase is a putative nuclear modifier gene for the phenotypic expression of the deafness-associated 12S rRNA mutations". Biochem. Biophys. Res. Commun. 342 (4): 1130–6. doi:10.1016/j.bbrc.2006.02.078. PMID 16513084.
• Guan MX, Yan Q, Li X, et al. (2006). "Mutation in TRMU Related to Transfer RNA Modification Modulates the Phenotypic Expression of the Deafness-Associated Mitochondrial 12S Ribosomal RNA Mutations". Am. J. Hum. Genet. 79 (2): 291–302. doi:10.1086/506389. PMC 1559489. PMID 16826519.