TSFM

Elongation factor Ts, mitochondrial is a protein that in humans is encoded by the TSFM gene. It is an EF-Ts homolog.[5][6]

TSFM
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2CP9
Identifiers
Aliases	TSFM, EFTS, EFTSMT, Ts translation elongation factor, mitochondrial
External IDs	OMIM: 604723 MGI: 1913649 HomoloGene: 4184 GeneCards: TSFM
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q14.1 Start 57,782,761 bp[1] End 57,808,071 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10|10 D3 Start 127,011,572 bp[2] End 127,030,840 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • translation elongation factor activity • RNA binding • GO:0001948 protein binding Cellular component • mitochondrial matrix • intracellular • mitochondrion • cell nucleus Biological process • translational elongation • regulation of DNA-templated transcription, elongation • protein biosynthesis • mitochondrial translational elongation • regulation of mitochondrial translation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10102	66399
Ensembl	ENSG00000123297	ENSMUSG00000040521
UniProt	P43897	Q9CZR8
RefSeq (mRNA)	NM_005726 NM_001172695 NM_001172696 NM_001172697	NM_025537
RefSeq (protein)	NP_001166166 NP_001166167 NP_001166168 NP_005717	NP_079813
Location (UCSC)	Chr 12: 57.78 – 57.81 Mb	Chr 10: 127.01 – 127.03 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000123297 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000040521 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Xin H, Woriax V, Burkhart W, Spremulli LL (Aug 1995). "Cloning and expression of mitochondrial translational elongation factor Ts from bovine and human liver". J Biol Chem. 270 (29): 17243–9. doi:10.1074/jbc.270.29.17243. PMID 7615523.
6. "Entrez Gene: TSFM Ts translation elongation factor, mitochondrial".

Further reading

• Smeitink JA, Elpeleg O, Antonicka H, et al. (2006). "Distinct clinical phenotypes associated with a mutation in the mitochondrial translation elongation factor EFTs". Am. J. Hum. Genet. 79 (5): 869–77. doi:10.1086/508434. PMC 1698578. PMID 17033963.
• Antonicka H, Sasarman F, Kennaway NG, Shoubridge EA (2006). "The molecular basis for tissue specificity of the oxidative phosphorylation deficiencies in patients with mutations in the mitochondrial translation factor EFG1". Hum. Mol. Genet. 15 (11): 1835–46. doi:10.1093/hmg/ddl106. PMID 16632485.
• Maksimov VV, Arman IP, Tarantul VZ (2006). "[Identification of the proteins interacting with neuroprotective peptide humanin in a yeast two-hybrid system]". Genetika. 42 (2): 274–7. PMID 16583711.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Vernon JL, Burr PC, Wiley JE, Farwell MA (2000). "Assignment of the mitochondrial translation elongation factor Ts gene (TSFM) to human chromosome 12 bands q13→q14 by in situ hybridization and with somatic cell hybrids". Cytogenet. Cell Genet. 89 (3–4): 145–6. doi:10.1159/000015596. PMID 10965106. S2CID 201991811.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Benkowski LA, Takemoto C, Ott G, et al. (1996). "Interaction of mitochondrial elongation factors Tu.Ts with aminoacyl-tRNA". Nucleic Acids Symp. Ser. (33): 163–6. PMID 8643359.

External links

• TSFM human gene location in the UCSC Genome Browser.
• TSFM human gene details in the UCSC Genome Browser.