TSHZ1

Teashirt zinc finger homeobox 1 is a protein that in humans is encoded by the TSHZ1 gene.[5]

TSHZ1
Identifiers
Aliases	TSHZ1, CAA, NY-CO-33, SDCCAG33, TSH1, teashirt zinc finger homeobox 1
External IDs	OMIM: 614427 MGI: 1346031 HomoloGene: 4227 GeneCards: TSHZ1
Gene location (Human) Chr. Chromosome 18 (human)[1] Band 18q22.3 Start 75,210,755 bp[1] End 75,289,950 bp[1]
Gene location (Mouse) Chr. Chromosome 18 (mouse)[2] Band 18 E4|18 57.53 cM Start 84,011,627 bp[2] End 84,087,706 bp[2]
Gene ontology Molecular function • DNA binding • metal ion binding • chromatin binding • GO:0001078, GO:0001214, GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific • nucleic acid binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component • cell nucleus Biological process • soft palate development • regulation of gene expression • regulation of transcription, DNA-templated • transcription, DNA-templated • anterior/posterior pattern specification • middle ear morphogenesis • multicellular organism development • regulation of transcription from RNA polymerase II promoter • negative regulation of transcription from RNA polymerase II promoter Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10194	110796
Ensembl	ENSG00000179981	ENSMUSG00000046982
UniProt	Q6ZSZ6	Q5DTH5
RefSeq (mRNA)	NM_001308210 NM_005786	NM_001081300 NM_001364993 NM_001364994
RefSeq (protein)	NP_001295139 NP_005777 NP_005777.3	NP_001074769 NP_001351922 NP_001351923
Location (UCSC)	Chr 18: 75.21 – 75.29 Mb	Chr 18: 84.01 – 84.09 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene encodes a colon cancer antigen that was defined by serological analysis of recombinant cDNA expression libraries. The encoded protein is a member of the teashirt C2H2-type zinc-finger protein family and may be involved in transcriptional regulation of developmental processes. Mutations in this gene may be associated with congenital aural atresia syndrome.

References

1. GRCh38: Ensembl release 89: ENSG00000179981 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000046982 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Teashirt zinc finger homeobox 1".

Further reading

• Schick B, Wemmert S, Willnecker V, Dlugaiczyk J, Nicolai P, Siwiec H, Thiel CT, Rauch A, Wendler O (November 2011). "Genome-wide copy number profiling using a 100K SNP array reveals novel disease-related genes BORIS and TSHZ1 in juvenile angiofibroma". International Journal of Oncology. 39 (5): 1143–51. doi:10.3892/ijo.2011.1166. PMID 21874228.
• Kajiwara Y, Akram A, Katsel P, Haroutunian V, Schmeidler J, Beecham G, Haines JL, Pericak-Vance MA, Buxbaum JD (2009). Bush AI (ed.). "FE65 binds Teashirt, inhibiting expression of the primate-specific caspase-4". PLOS ONE. 4 (4): e5071. doi:10.1371/journal.pone.0005071. PMC 2660419. PMID 19343227.
• Scanlan MJ, Chen YT, Williamson B, Gure AO, Stockert E, Gordan JD, Türeci O, Sahin U, Pfreundschuh M, Old LJ (May 1998). "Characterization of human colon cancer antigens recognized by autologous antibodies". International Journal of Cancer. 76 (5): 652–8. doi:10.1002/(SICI)1097-0215(19980529)76:5<652::AID-IJC7>3.0.CO;2-P. PMID 9610721.
• Coré N, Caubit X, Metchat A, Boned A, Djabali M, Fasano L (August 2007). "Tshz1 is required for axial skeleton, soft palate and middle ear development in mice". Developmental Biology. 308 (2): 407–20. doi:10.1016/j.ydbio.2007.05.038. PMID 17586487.
• Feenstra I, Vissers LE, Pennings RJ, Nillessen W, Pfundt R, Kunst HP, Admiraal RJ, Veltman JA, van Ravenswaaij-Arts CM, Brunner HG, Cremers CW (December 2011). "Disruption of teashirt zinc finger homeobox 1 is associated with congenital aural atresia in humans". American Journal of Human Genetics. 89 (6): 813–9. doi:10.1016/j.ajhg.2011.11.008. PMC 3234381. PMID 22152683.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.