TTC1

Tetratricopeptide repeat protein 1 is a protein that in humans is encoded by the TTC1 gene.[4][5]

TTC1
Identifiers
Aliases	TTC1, TPR1, tetratricopeptide repeat domain 1
External IDs	OMIM: 601963 MGI: 1914077 HomoloGene: 2485 GeneCards: TTC1
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q33.3 Start 160,009,113 bp[1] End 160,065,543 bp[1]
RNA expression pattern More reference expression data
Gene ontology Molecular function • unfolded protein binding • GO:0001948 protein binding Cellular component • peroxisomal membrane • cytosol Biological process • protein folding Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	7265	66827
Ensembl	ENSG00000113312	ENSMUSG00000041278
UniProt	Q99614	Q91Z38
RefSeq (mRNA)	NM_003314 NM_001282500	NM_133795
RefSeq (protein)	NP_001269429 NP_003305	NP_598556
Location (UCSC)	Chr 5: 160.01 – 160.07 Mb	n/a
PubMed search	[2]	[3]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

TTC1 has been shown to interact with HSPA4.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000113312 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. Murthy AE, Bernards A, Church D, Wasmuth J, Gusella JF (Nov 1996). "Identification and characterization of two novel tetratricopeptide repeat-containing genes". DNA Cell Biol. 15 (9): 727–35. doi:10.1089/dna.1996.15.727. PMID 8836031.
5. "Entrez Gene: TTC1 tetratricopeptide repeat domain 1".
6. Oh, Won-Kyung; Song Jaewhan (Aug 2003). "Cooperative interaction of Hsp40 and TPR1 with Hsp70 reverses Hsp70-HspBp1 complex formation". Mol. Cells. Korea (South). 16 (1): 84–91. ISSN 1016-8478. PMID 14503850.

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Marty C, Browning DD, Ye RD (2003). "Identification of tetratricopeptide repeat 1 as an adaptor protein that interacts with heterotrimeric G proteins and the small GTPase Ras". Mol. Cell. Biol. 23 (11): 3847–58. doi:10.1128/MCB.23.11.3847-3858.2003. PMC 155206. PMID 12748287.
• Oh WK, Song J (2004). "Cooperative interaction of Hsp40 and TPR1 with Hsp70 reverses Hsp70-HspBp1 complex formation". Mol. Cells. 16 (1): 84–91. PMID 14503850.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715): 1621–5. Bibcode:2005Sci...307.1621B. doi:10.1126/science.1105776. PMID 15761153. S2CID 39457788.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.