TTC4

Tetratricopeptide repeat protein 4 is a protein that in humans is encoded by the TTC4 gene.[5][6]

TTC4
Identifiers
Aliases	TTC4, tetratricopeptide repeat domain 4, CNS1
External IDs	OMIM: 606753 MGI: 1919604 HomoloGene: 31249 GeneCards: TTC4
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p32.3 Start 54,715,861 bp[1] End 54,742,657 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 C7 Start 106,662,256 bp[2] End 106,678,944 bp[2]
Orthologs
Species	Human	Mouse
Entrez	7268	72354
Ensembl	ENSG00000243725	ENSMUSG00000025413
UniProt	O95801	Q8R3H9
RefSeq (mRNA)	NM_004623 NM_001291333	NM_001172073 NM_028209
RefSeq (protein)	NP_001278262 NP_004614	NP_001165544 NP_082485
Location (UCSC)	Chr 1: 54.72 – 54.74 Mb	Chr 4: 106.66 – 106.68 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

The 34-amino acid tetratricopeptide repeat (TPR) motif is found in a variety of proteins and may mediate protein-protein or protein-membrane interactions.[supplied by OMIM][6]

References

1. GRCh38: Ensembl release 89: ENSG00000243725 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000025413 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Su G, Roberts T, Cowell JK (Sep 1999). "TTC4, a novel human gene containing the tetratricopeptide repeat and mapping to the region of chromosome 1p31 that is frequently deleted in sporadic breast cancer". Genomics. 55 (2): 157–63. doi:10.1006/geno.1998.5633. PMID 9933562.
6. "Entrez Gene: TTC4 tetratricopeptide repeat domain 4".

Further reading

• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Lan S, Wang H, Jiang H, et al. (2003). "Direct interaction between alpha-actinin and hepatitis C virus NS5B". FEBS Lett. 554 (3): 289–94. doi:10.1016/S0014-5793(03)01163-3. PMID 14623081.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Hey Y, Brintnell B, James LA, Varley JM (2000). "Assignment of TTC4 to human chromosome band 1p31.3 and a pseudogene TTC4P to 7p14→p13 by in situ hybridization". Cytogenet. Cell Genet. 88 (3–4): 272–4. doi:10.1159/000015536. PMID 10828607.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.