TTF2

Transcription termination factor 2 is a protein that in humans is encoded by the TTF2 gene.[5][6]

TTF2
Identifiers
Aliases	TTF2, HuF2, ZGRF6, transcription termination factor, RNA polymerase II, transcription termination factor 2
External IDs	OMIM: 604718 MGI: 1921294 HomoloGene: 37826 GeneCards: TTF2
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p13.1 Start 117,060,326 bp[1] End 117,107,453 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 F2.2 Start 100,938,860 bp[2] End 100,969,663 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • DNA binding • nucleotide binding • DNA-dependent ATPase activity • zinc ion binding • GO:0001948 protein binding • ATP binding • GO:0008026 helicase activity • hydrolase activity Cellular component • spliceosomal complex • transcription elongation factor complex • cell nucleus • cytoplasm • cytosol Biological process • DNA-templated transcription, termination • termination of RNA polymerase II transcription • mRNA processing • regulation of transcription, DNA-templated • RNA splicing • transcription, DNA-templated Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	8458	74044
Ensembl	ENSG00000116830	ENSMUSG00000033222
UniProt	Q9UNY4	Q5NC05
RefSeq (mRNA)	NM_003594	NM_001013026
RefSeq (protein)	NP_003585	NP_001013044
Location (UCSC)	Chr 1: 117.06 – 117.11 Mb	Chr 3: 100.94 – 100.97 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a member of the SWI2/SNF2 family of proteins, which play a critical role in altering protein-DNA interactions. The encoded protein has been shown to have dsDNA-dependent ATPase activity and RNA polymerase II termination activity. This protein interacts with cell division cycle 5-like, associates with human splicing complexes, and plays a role in pre-mRNA splicing.[6]

Interactions

TTF2 has been shown to interact with CDC5L.[7]

References

1. GRCh38: Ensembl release 89: ENSG00000116830 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000033222 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Liu M, Xie Z, Price DH (October 1998). "A human RNA polymerase II transcription termination factor is a SWI2/SNF2 family member". The Journal of Biological Chemistry. 273 (40): 25541–4. doi:10.1074/jbc.273.40.25541. PMID 9748214.
6. "Entrez Gene: TTF2 transcription termination factor, RNA polymerase II".
7. Leonard D, Ajuh P, Lamond AI, Legerski RJ (September 2003). "hLodestar/HuF2 interacts with CDC5L and is involved in pre-mRNA splicing". Biochemical and Biophysical Research Communications. 308 (4): 793–801. CiteSeerX 10.1.1.539.8359. doi:10.1016/S0006-291X(03)01486-4. PMID 12927788.

Further reading

• Girdham CH, Glover DM (October 1991). "Chromosome tangling and breakage at anaphase result from mutations in lodestar, a Drosophila gene encoding a putative nucleoside triphosphate-binding protein". Genes & Development. 5 (10): 1786–99. doi:10.1101/gad.5.10.1786. PMID 1916263.
• Hara R, Selby CP, Liu M, Price DH, Sancar A (August 1999). "Human transcription release factor 2 dissociates RNA polymerases I and II stalled at a cyclobutane thymine dimer". The Journal of Biological Chemistry. 274 (35): 24779–86. doi:10.1074/jbc.274.35.24779. PMID 10455150.
• Leonard D, Ajuh P, Lamond AI, Legerski RJ (September 2003). "hLodestar/HuF2 interacts with CDC5L and is involved in pre-mRNA splicing". Biochemical and Biophysical Research Communications. 308 (4): 793–801. CiteSeerX 10.1.1.539.8359. doi:10.1016/S0006-291X(03)01486-4. PMID 12927788.
• Jiang Y, Liu M, Spencer CA, Price DH (May 2004). "Involvement of transcription termination factor 2 in mitotic repression of transcription elongation". Molecular Cell. 14 (3): 375–85. doi:10.1016/S1097-2765(04)00234-5. PMID 15125840.
• Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM (July 2004). "Functional proteomics mapping of a human signaling pathway". Genome Research. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
• Jiang Y, Price DH (September 2004). "Rescue of the TTF2 knockdown phenotype with an siRNA-resistant replacement vector". Cell Cycle. 3 (9): 1151–3. doi:10.4161/cc.3.9.1151. PMID 15467445.