TTLL1

Probable tubulin polyglutamylase TTLL1 is an enzyme that in humans is encoded by the TTLL1 gene.[5][6][7]

TTLL1
Identifiers
Aliases	TTLL1, C22orf7, HS323M22B, tubulin tyrosine ligase like 1
External IDs	OMIM: 608955 MGI: 2443047 HomoloGene: 8174 GeneCards: TTLL1
Gene location (Human) Chr. Chromosome 22 (human)[1] Band 22q13.2 Start 43,039,516 bp[1] End 43,089,419 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15|15 E1 Start 83,483,769 bp[2] End 83,510,893 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • nucleotide binding • ligase activity • ATP binding • tubulin-glutamic acid ligase activity Cellular component • cytoplasm • microtubules • cytoskeleton • extracellular region Biological process • epithelial cilium movement • protein polyglutamylation • cellular protein modification process • axoneme assembly • sperm axoneme assembly Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	25809	319953
Ensembl	ENSG00000100271	ENSMUSG00000022442
UniProt	O95922	Q91V51
RefSeq (mRNA)	NM_001008572 NM_012263	NM_178869 NM_001357953
RefSeq (protein)	NP_036395	NP_849200 NP_001344882
Location (UCSC)	Chr 22: 43.04 – 43.09 Mb	Chr 15: 83.48 – 83.51 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000100271 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000022442 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP, et al. (Dec 1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208.
6. Trichet V, Ruault M, Roizes G, De Sario A (Dec 2000). "Characterization of the human tubulin tyrosine ligase-like 1 gene (TTLL1) mapping to 22q13.1". Gene. 257 (1): 109–17. doi:10.1016/S0378-1119(00)00383-8. PMID 11054573.
7. "Entrez Gene: TTLL1 tubulin tyrosine ligase-like family, member 1".

Further reading

• Nagase T, Seki N, Ishikawa K, et al. (1996). "Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 3 (1): 17–24. doi:10.1093/dnares/3.1.17. PMID 8724849.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Collins JE, Goward ME, Cole CG, et al. (2003). "Reevaluating Human Gene Annotation: A Second-Generation Analysis of Chromosome 22". Genome Res. 13 (1): 27–36. doi:10.1101/gr.695703. PMC 430954. PMID 12529303.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMC 545604. PMID 15461802.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Janke C, Rogowski K, Wloga D, et al. (2005). "Tubulin polyglutamylase enzymes are members of the TTL domain protein family". Science. 308 (5729): 1758–62. doi:10.1126/science.1113010. PMID 15890843.