TUBE1

Tubulin, epsilon 1 is a protein in humans that is encoded by the TUBE1 gene.[5] This gene encodes a member of the tubulin superfamily. This protein localizes to the centriolar sub-distal appendages that are associated with the older of the two centrioles after centrosome duplication. This protein plays a central role in organization of the microtubules during centriole duplication

TUBE1
Identifiers
Aliases	TUBE1, TUBE, dJ142L7.2, tubulin epsilon 1
External IDs	OMIM: 607345 MGI: 1919174 HomoloGene: 17762 GeneCards: TUBE1
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6q21 Start 112,070,663 bp[1] End 112,087,529 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10|10 B1 Start 39,133,976 bp[2] End 39,152,542 bp[2]
Gene ontology Molecular function • nucleotide binding • GTP binding • structural constituent of cytoskeleton • GTPase activity Cellular component • cytoplasm • microtubules • pericentriolar material • cytoskeleton • microtubule organizing center Biological process • centrosome cycle • microtubule-based process • microtubule cytoskeleton organization • GO:0007067 mitotic cell cycle Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	51175	71924
Ensembl	ENSG00000074935	ENSMUSG00000019845
UniProt	Q9UJT0	Q9D6T1
RefSeq (mRNA)	NM_016262	NM_028006
RefSeq (protein)	NP_057346	NP_082282
Location (UCSC)	Chr 6: 112.07 – 112.09 Mb	Chr 10: 39.13 – 39.15 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000074935 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000019845 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Tubulin, epsilon 1".

Further reading

• Chang P, Giddings TH, Winey M, Stearns T (January 2003). "Epsilon-tubulin is required for centriole duplication and microtubule organization". Nature Cell Biology. 5 (1): 71–6. doi:10.1038/ncb900. PMID 12510196. S2CID 1318660.
• Zanic M, Stear JH, Hyman AA, Howard J (October 2009). May RC (ed.). "EB1 recognizes the nucleotide state of tubulin in the microtubule lattice". PLOS ONE. 4 (10): e7585. doi:10.1371/journal.pone.0007585. PMC 2761489. PMID 19851462.
• Chang P, Stearns T (January 2000). "Delta-tubulin and epsilon-tubulin: two new human centrosomal tubulins reveal new aspects of centrosome structure and function". Nature Cell Biology. 2 (1): 30–5. doi:10.1038/71350. PMID 10620804. S2CID 23500269.