TUSC3

Tumor suppressor candidate 3 is a protein that in humans is encoded by the TUSC3 gene.[5][6][7]

TUSC3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4M8G, 4M90, 4M91, 4M92
Identifiers
Aliases	TUSC3, D8S1992, M33, MRT22, MRT7, N33, OST3A, tumor suppressor candidate 3, MagT2, SLC58A2
External IDs	OMIM: 601385 MGI: 1933134 HomoloGene: 6937 GeneCards: TUSC3
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8p22 Start 15,417,215 bp[1] End 15,766,649 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8|8 A4 Start 39,005,845 bp[2] End 39,165,114 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • magnesium ion transmembrane transporter activity • dolichyl-diphosphooligosaccharide-protein glycotransferase activity Cellular component • integral component of membrane • oligosaccharyltransferase complex • cell membrane • integral component of plasma membrane • endoplasmic reticulum membrane • endoplasmic reticulum • membrane • mitochondrion Biological process • protein N-linked glycosylation • magnesium ion transport • cognition • transmembrane transport • magnesium ion transmembrane transport • protein glycosylation • protein N-linked glycosylation via asparagine Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	7991	80286
Ensembl	ENSG00000104723	ENSMUSG00000039530
UniProt	Q13454	Q8BTV1
RefSeq (mRNA)	NM_006765 NM_178234 NM_001356429	NM_030254 NM_001357304 NM_001357305 NM_001357306
RefSeq (protein)	NP_006756 NP_839952 NP_001343358	NP_084530 NP_001344233 NP_001344234 NP_001344235
Location (UCSC)	Chr 8: 15.42 – 15.77 Mb	Chr 8: 39.01 – 39.17 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

This gene is a candidate tumor suppressor gene. It is located within a deleted region of a metastatic prostate cancer. The gene is expressed in most nonlymphoid human tissues including prostate, lung, liver, and colon. Expression was also detected in many epithelial tumor cell lines. Two transcript variants encoding distinct isoforms have been identified for this gene.[7]

References

1. GRCh38: Ensembl release 89: ENSG00000104723 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000039530 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. MacGrogan D, Levy A, Bova GS, Isaacs WB, Bookstein R (Sep 1996). "Structure and methylation-associated silencing of a gene within a homozygously deleted region of human chromosome band 8p22". Genomics. 35 (1): 55–65. doi:10.1006/geno.1996.0322. PMID 8661104.
6. Ishii H, Baffa R, Numata SI, Murakumo Y, Rattan S, Inoue H, Mori M, Fidanza V, Alder H, Croce CM (May 1999). "The FEZ1 gene at chromosome 8p22 encodes a leucine-zipper protein, and its expression is altered in multiple human tumors". Proc Natl Acad Sci U S A. 96 (7): 3928–33. Bibcode:1999PNAS...96.3928I. doi:10.1073/pnas.96.7.3928. PMC 22397. PMID 10097140.
7. "Entrez Gene: TUSC3 tumor suppressor candidate 3".

Further reading

• Pak BJ, Park H, Chang ER, et al. (1998). "Differential display analysis of oxygen-mediated changes in gene expression in first trimester human trophoblast cells". Placenta. 19 (7): 483–8. doi:10.1016/S0143-4004(98)91041-4. PMID 9778121.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Kelleher DJ, Karaoglu D, Mandon EC, Gilmore R (2003). "Oligosaccharyltransferase isoforms that contain different catalytic STT3 subunits have distinct enzymatic properties". Mol. Cell. 12 (1): 101–11. doi:10.1016/S1097-2765(03)00243-0. PMID 12887896.
• Anderson NL, Polanski M, Pieper R, et al. (2004). "The human plasma proteome: a nonredundant list developed by combination of four separate sources". Mol. Cell. Proteomics. 3 (4): 311–26. doi:10.1074/mcp.M300127-MCP200. PMID 14718574.
• Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Shibatani T, David LL, McCormack AL, et al. (2005). "Proteomic analysis of mammalian oligosaccharyltransferase reveals multiple subcomplexes that contain Sec61, TRAP, and two potential new subunits". Biochemistry. 44 (16): 5982–92. doi:10.1021/bi047328f. PMID 15835887.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Pils D, Horak P, Gleiss A, et al. (2006). "Five genes from chromosomal band 8p22 are significantly down-regulated in ovarian carcinoma: N33 and EFA6R have a potential impact on overall survival". Cancer. 104 (11): 2417–29. doi:10.1002/cncr.21538. PMID 16270321. S2CID 26030376.
• Guervós MA, Marcos CA, Hermsen M, et al. (2007). "Deletions of N33, STK11 and TP53 are involved in the development of lymph node metastasis in larynx and pharynx carcinomas". Cell. Oncol. 29 (4): 327–34. doi:10.1155/2007/635962. PMC 4618212. PMID 17641416.