TWF2

Twinfilin-2 is a protein that in humans is encoded by the TWF2 gene.[5][6][7]

TWF2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2VAC, 2W0I
Identifiers
Aliases	TWF2, A6RP, A6r, PTK9L, MSTP011, twinfilin actin binding protein 2
External IDs	OMIM: 607433 MGI: 1346078 HomoloGene: 5272 GeneCards: TWF2
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3p21.2 Start 52,228,612 bp[1] End 52,239,158 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 F1 Start 106,203,108 bp[2] End 106,215,389 bp[2]
Gene ontology Molecular function • actin monomer binding • GO:0001948 protein binding • actin binding • phosphatidylinositol-4,5-bisphosphate binding • ATP binding • protein kinase C binding • RNA binding • cadherin binding • actin filament binding Cellular component • cell projection • filopodium • growth cone • intracellular • stereocilium • perinuclear region of cytoplasm • extracellular exosome • cytoskeleton • lamellipodium • cytoplasm • myofibril • actin filament Biological process • cellular response to retinoic acid • regulation of actin cytoskeleton organization • negative regulation of actin filament polymerization • cellular response to growth factor stimulus • cell projection organization • positive regulation of neuron projection development • positive regulation of axon extension • positive regulation of lamellipodium assembly • regulation of microvillus length • sequestering of actin monomers • barbed-end actin filament capping • regulation of lamellipodium assembly • actin filament depolymerization Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	11344	23999
Ensembl	ENSG00000247596	ENSMUSG00000023277
UniProt	Q6IBS0	Q9Z0P5
RefSeq (mRNA)	NM_007284	NM_011876
RefSeq (protein)	NP_009215	NP_036006
Location (UCSC)	Chr 3: 52.23 – 52.24 Mb	Chr 9: 106.2 – 106.22 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

The protein encoded by this gene was identified by its interaction with the catalytic domain of protein kinase C-zeta. The encoded protein contains an actin-binding site and an ATP-binding site. It is most closely related to twinfilin (PTK9), a conserved actin monomer-binding protein.[7]

References

1. GRCh38: Ensembl release 89: ENSG00000247596 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000023277 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Rohwer A, Kittstein W, Marks F, Gschwendt M (Aug 1999). "Cloning, expression and characterization of an A6-related protein". Eur J Biochem. 263 (2): 518–25. doi:10.1046/j.1432-1327.1999.00537.x. PMID 10406962.
6. Vartiainen MK, Sarkkinen EM, Matilainen T, Salminen M, Lappalainen P (Sep 2003). "Mammals have two twinfilin isoforms whose subcellular localizations and tissue distributions are differentially regulated". J Biol Chem. 278 (36): 34347–55. doi:10.1074/jbc.M303642200. PMID 12807912.
7. "Entrez Gene: TWF2 twinfilin, actin-binding protein, homolog 2 (Drosophila)".

Further reading

• Yamada S, Uchimura E, Ueda T, et al. (2007). "Identification of twinfilin-2 as a factor involved in neurite outgrowth by RNAi-based screen". Biochem. Biophys. Res. Commun. 363 (4): 926–30. doi:10.1016/j.bbrc.2007.09.069. PMID 17910947.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
• Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455. S2CID 7200157.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.