TXNL4A

Thioredoxin-like protein 4A is a protein that is encoded by the TXNL4A gene in humans.[4][5]

TXNL4A
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1PQN, 1QGV, 1SYX, 4BWQ, 4BWS, 4CDO, 3JCR
Identifiers
Aliases	TXNL4A, DIB1, DIM1, HsT161, SNRNP15, TXNL4, U5-15kD, BMKS, thioredoxin like 4A
External IDs	OMIM: 611595 MGI: 1351613 HomoloGene: 7150 GeneCards: TXNL4A
Gene location (Human) Chr. Chromosome 18 (human)[1] Band 18q23 Start 79,970,813 bp[1] End 80,033,949 bp[1]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding Cellular component • U5 snRNP • spliceosomal complex • nucleoplasm • cell nucleus • cytosol • not the membrane • U4/U6 x U5 tri-snRNP complex • U2-type precatalytic spliceosome Biological process • RNA splicing, via transesterification reactions • mRNA splicing, via spliceosome • cell cycle • mRNA processing • spliceosomal complex assembly • cell division • RNA splicing Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10907	27366
Ensembl	ENSG00000141759	ENSMUSG00000057130
UniProt	P83876	P83877
RefSeq (mRNA)	NM_001303471 NM_001305557 NM_001305563 NM_001305564 NM_006701	NM_001038608 NM_001042408 NM_001042409 NM_025299 NM_178604
RefSeq (protein)	NP_001290400 NP_001292486 NP_001292492 NP_001292493 NP_006692	NP_001033697 NP_001035867 NP_079575 NP_848719 NP_001371102 NP_001371103 NP_001371104 NP_001371105 NP_001371106
Location (UCSC)	Chr 18: 79.97 – 80.03 Mb	n/a
PubMed search	[2]	[3]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

TXNL4A has been shown to interact with PQBP1.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000141759 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. Zhang YZ, Gould KL, Dunbrack RL JR, Cheng H, Roder H, Golemis EA (October 2000). "The evolutionarily conserved Dim1 protein defines a novel branch of the thioredoxin fold superfamily". Physiol Genomics. 1 (3): 109–18. doi:10.1152/physiolgenomics.1999.1.3.109. PMID 11015569.
5. "Entrez Gene: TXNL4A thioredoxin-like 4A".
6. Zhang Y, Lindblom T, Chang A, Sudol M, Sluder AE, Golemis EA (October 2000). "Evidence that dim1 associates with proteins involved in pre-mRNA splicing, and delineation of residues essential for dim1 interactions with hnRNP F and Npw38/PQBP-1". Gene. 257 (1): 33–43. doi:10.1016/S0378-1119(00)00372-3. PMID 11054566.

Further reading

• Reuter K, Nottrott S, Fabrizio P, Lührmann R, Ficner R (2000). "Identification, characterization and crystal structure analysis of the human spliceosomal U5 snRNP-specific 15 kD protein". J. Mol. Biol. 294 (2): 515–25. doi:10.1006/jmbi.1999.3258. PMID 10610776.
• Zhang Y, Lindblom T, Chang A, Sudol M, Sluder AE, Golemis EA (2001). "Evidence that dim1 associates with proteins involved in pre-mRNA splicing, and delineation of residues essential for dim1 interactions with hnRNP F and Npw38/PQBP-1". Gene. 257 (1): 33–43. doi:10.1016/S0378-1119(00)00372-3. PMID 11054566.
• Zhang YZ, Cheng H, Gould KL, Golemis EA, Roder H (2003). "Structure, stability, and function of hDim1 investigated by NMR, circular dichroism, and mutational analysis". Biochemistry. 42 (32): 9609–18. doi:10.1021/bi034486i. PMID 12911302.
• Laggerbauer B, Liu S, Makarov E, Vornlocher HP, Makarova O, Ingelfinger D, Achsel T, Lührmann R (2005). "The human U5 snRNP 52K protein (CD2BP2) interacts with U5-102K (hPrp6), a U4/U6.U5 tri-snRNP bridging protein, but dissociates upon tri-snRNP formation" (PDF). RNA. 11 (5): 598–608. doi:10.1261/rna.2300805. PMC 1370748. PMID 15840814.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Jin T, Guo F, Wang Y, Zhang YZ (2007). "Identification of human dim1 as a peptidase with autocleavage activity". Chemical Biology & Drug Design. 68 (5): 266–72. doi:10.1111/j.1747-0285.2006.00447.x. PMID 17177886. S2CID 13020526.