TYSND1

Trypsin domain containing 1 is a protein that in humans is encoded by the TYSND1 gene. [5]

TYSND1
Identifiers
Aliases	TYSND1, NET41, trypsin domain containing 1
External IDs	OMIM: 611017 MGI: 1919017 HomoloGene: 87946 GeneCards: TYSND1
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10q22.1 Start 70,137,981 bp[1] End 70,146,700 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10|10 B4 Start 61,695,514 bp[2] End 61,702,773 bp[2]
Gene ontology Molecular function • protease binding • peptidase activity • serine-type peptidase activity • hydrolase activity • identical protein binding • serine-type endopeptidase activity Cellular component • peroxisome • membrane • peroxisomal matrix • cytosol Biological process • protein processing • regulation of fatty acid beta-oxidation • protein homooligomerization • proteolysis • protein targeting to peroxisome Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	219743	71767
Ensembl	ENSG00000156521	ENSMUSG00000020087
UniProt	Q2T9J0	Q9DBA6
RefSeq (mRNA)	NM_001040273 NM_173555	NM_001272090 NM_001272091 NM_001272092 NM_027912
RefSeq (protein)	NP_001035363 NP_775826	NP_001259019 NP_001259020 NP_001259021 NP_082188
Location (UCSC)	Chr 10: 70.14 – 70.15 Mb	Chr 10: 61.7 – 61.7 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene encodes a protease that removes the N-terminal peroxisomal targeting signal (PTS2) from proteins produced in the cytosol, thereby facilitating their import into the peroxisome.

The encoded protein is also capable of cleaving several proteins targeted to peroxisomes through the C-terminal peroxisomal targeting signal (PTS1). The full-length protein undergoes self-cleavage to produce shorter, potentially inactive fragments. Alternative splicing results in multiple transcript variants for this gene.

References

1. GRCh38: Ensembl release 89: ENSG00000156521 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000020087 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Trypsin domain containing 1". Retrieved 2017-10-02.

Further reading

• Grupe A, Li Y, Rowland C, Nowotny P, Hinrichs AL, Smemo S, Kauwe JS, Maxwell TJ, Cherny S, Doil L, Tacey K, van Luchene R, Myers A, Wavrant-De Vrièze F, Kaleem M, Hollingworth P, Jehu L, Foy C, Archer N, Hamilton G, Holmans P, Morris CM, Catanese J, Sninsky J, White TJ, Powell J, Hardy J, O'Donovan M, Lovestone S, Jones L, Morris JC, Thal L, Owen M, Williams J, Goate A (2006). "A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease". Am. J. Hum. Genet. 78 (1): 78–88. doi:10.1086/498851. PMC 1380225. PMID 16385451.
• Kurochkin IV, Mizuno Y, Konagaya A, Sakaki Y, Schönbach C, Okazaki Y (2007). "Novel peroxisomal protease Tysnd1 processes PTS1- and PTS2-containing enzymes involved in beta-oxidation of fatty acids". EMBO J. 26 (3): 835–45. doi:10.1038/sj.emboj.7601525. PMC 1794383. PMID 17255948.
• Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.