Tal Danino

Tal Danino is a synthetic biologist and assistant professor of biomedical engineering at Columbia University.[1]

Tal Danino
AwardsTED Fellow, Department of Defense Era of Hope Scholar
Academic background
Alma materUniversity of California, Los Angeles (B.S., 2005) University of California, San Diego (PhD., 2011)
ThesisSynthetic gene oscillators and their applications
Doctoral advisorJeff Hasty
Academic work
DisciplineSynthetic Biology
InstitutionsMassachusetts Institute of Technology Columbia University
Websitetaldanino.com

Education

Danino graduated from the University of California, Los Angeles with Bachelor of Science degrees in physics, mathematics and chemistry. He received a Master of Science and Doctor of Philosophy in bioengineering from the University of California, San Diego, and completed postdoctoral training at the Massachusetts Institute of Technology.[2]

Research

Danino’s research focuses on the design and characterization of dynamic gene circuits in microbes with applications such as cancer diagnostics and therapeutics, summarized in a 2015 TED talk.[3]

For his PhD thesis, he worked in Jeff Hasty's laboratory at UCSD, where he created synchronized oscillations in bacterial populations through synthetic biological circuits that combined positive and negative feedback with a fluorescent reporter.[4] The resulting paper and corresponding video were published in Nature in 2010.[5]

As a postdoctoral scientist at MIT, he worked in Sangeeta Bhatia's laboratory at the Koch Institute for Integrative Cancer Research, where he used probiotics to colonize tumors and detect their presence in urine via a color-changing molecule, resulting in a publication in Science Translational Medicine in 2015.[6] Here he also characterized an engineered strain of S. typhimurium for the sustained release of cancer therapeutics, which was published in Nature in 2016.[7]

He runs the Synthetic Biological Systems Laboratory at Columbia University, focuses on treating cancer with probiotic bacteria, in addition to dynamic gene circuit design of spatiotemporal behaviors.

Artworks

Danino creates visual art involving bacteria and cells and encompassing various themes, often exploring the relationship of humans to microorganisms. His works have gained significant attention and have been featured in the New York Times,[8][9] The Atlantic,[10] and Wired magazine.[11] He has collaborated with artists such as Vik Muniz in the Colonies series, where he developed a photolithography based printing process to create intricate patterns out of both bacterial and cancer cells.[12][13] Also in collaboration with Vik Muniz and created by Bernardaud was the Petri collection, a set of porcelain dinner plates depicting pathogenic bacteria.[14][15] Tal has worked with other artists such as Anicka Yi, exploring concepts of biological identity.[16][17] In Microuniverse, he used artistic processes such as silk screening to display a variety of petri-dish grown bacterial colonies on different color backgrounds to show their wide range of growth morphologies, from rings to fractals.[18]

References
  1. "Synthetic Biological Systems Laboratory".
  2. "Columbia University Biomedical Engineering: Tal Danino".
  3. "Programming bacteria to detect cancer (and maybe treat it)". TED.com.
  4. "Synthetic gene oscillators and their applications".
  5. "A synchronized quorum of genetic clocks".
  6. "Programmable probiotics for detection of cancer in urine".
  7. "Synchronized cycles of bacterial lysis for in vivo delivery".
  8. "Gates Foundation Uses Art to Encourage Vaccination".
  9. "At M.I.T., Science Embraces a New Chaos Theory: Art".
  10. "The Devil Wears Pulsars".
  11. "A Beautiful Wallpaper Made With Smallpox Vaccine".
  12. "Colonies: Vik Muniz And Tal Danino Turn Living Cells Into Art".
  13. "Turning cancer cells, bacteria into amazing art".
  14. "Eating out of the petri dish: Vik Muniz and Tal Danino's bacterial tableware for Bernardaud".
  15. "VIK MUNIZ X TAL DANINO : Petri Set of Six Dinner Plates by Bernard".
  16. "The Sights (and Smells) of Anicka Yi's Bacteria Art Show".
  17. "Anicka Yi's olfactory art".
  18. "The most beautiful bacteria you'll ever see".
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