Tubulointerstitial nephritis and uveitis

Tubulointerstitial nephritis and uveitis (TINU) is a rare medical condition in which there is uveitis (inflammation of the uvea in the eye) together with tubulointerstitial nephritis (inflammation of the tubules inside the kidney).

Tubulointerstitial nephritis and uveitis
Other names	Acute tubulointerstitial nephritis and uveitis syndrome
Specialty	Ophthalmology

Symptoms and signs

Uveitis may cause pain of the affected eye together with changes in vision. It may be accompanied by nonspecific systemic symptoms such as fever, involuntary weight loss, fatigue, loss of appetite, abdominal pain, and joint pains.[1]

Prevalence

It is a very rare disease. Approximately 200 cases were reported in medical journals in the 35 years after its initial description.[1] Altogether, more than 100 cases have been reported in Japan.[2]

History

It was first described in 1975.[1][3]

References

1. Mackensen, F; Billing, H (November 2009). "Tubulointerstitial nephritis and uveitis syndrome". Current Opinion in Ophthalmology. 20 (6): 525–31. doi:10.1097/ICU.0b013e3283318f9a. PMID 19752730. S2CID 11461472.
2. Matsumoto, Keiichiro; Fukunari, Kenichi; Ikeda, Yuji; Miyazono, Motoaki; Kishi, Tomoya; Matsumoto, Ryoko; Fukuda, Makoto; Uchiumi, Saori; Yoshizaki, Mai (2015-01-01). "A report of an adult case of tubulointerstitial nephritis and uveitis (TINU) syndrome, with a review of 102 Japanese cases". The American Journal of Case Reports. 16: 119–123. doi:10.12659/AJCR.892788. ISSN 1941-5923. PMC 4347719. PMID 25725230.
3. Dobrin, RS; Vernier, RL; Fish, AL (September 1975). "Acute eosinophilic interstitial nephritis and renal failure with bone marrow-lymph node granulomas and anterior uveitis. A new syndrome". The American Journal of Medicine. 59 (3): 325–33. doi:10.1016/0002-9343(75)90390-3. PMID 1163543.

External links

Classification	D ICD-10: Xxx.x ICD-9-CM: xxx OMIM: 607665
External resources	Orphanet: 91500