Turnip crinkle virus (TCV) repressor of minus strand synthesis H5
The TCV hairpin 5 (H5) is an RNA element found in the turnip crinkle virus. This RNA element is composed of a stem-loop that contains a large symmetrical internal loop (LSL). H5 can repress minus-strand synthesis when the 3' side of the LSL pairs with the 4 bases at the 3'-terminus of the RNA(GCCC-OH).[1][2]
| Turnip crinkle virus (TCV) repressor of minus strand synthesis H5 | |
|---|---|
 Predicted secondary structure and sequence conservation of TCV_H5 | |
| Identifiers | |
| Symbol | TCV_H5 |
| Rfam | RF00500 |
| Other data | |
| RNA type | Cis-reg |
| Domain(s) | Viruses |
| SO | SO:0000233 |
| PDB structures | PDBe |
References
- McCormack JC, Simon AE (July 2004). "Biased hypermutagenesis associated with mutations in an untranslated hairpin of an RNA virus". Journal of Virology. 78 (14): 7813–7817. doi:10.1128/JVI.78.14.7813-7817.2004. PMC 434097. PMID 15220455.
- Zhang G, Zhang J, Simon AE (July 2004). "Repression and derepression of minus-strand synthesis in a plus-strand RNA virus replicon". Journal of Virology. 78 (14): 7619–7633. doi:10.1128/JVI.78.14.7619-7633.2004. PMC 434078. PMID 15220437.
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