UACA

Uveal autoantigen with coiled-coil domains and ankyrin repeats is a protein that in humans is encoded by the UACA gene.[5][6][7]

UACA
Identifiers
Aliases	UACA, NUCLING, uveal autoantigen with coiled-coil domains and ankyrin repeats
External IDs	OMIM: 612516 MGI: 1919815 HomoloGene: 74297 GeneCards: UACA
Gene location (Human) Chr. Chromosome 15 (human)[1] Band 15q23 Start 70,654,554 bp[1] End 70,763,558 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 B Start 60,794,542 bp[2] End 60,880,370 bp[2]
Gene ontology Molecular function • GO:0001948 protein binding • molecular function Cellular component • extracellular region • extracellular exosome • cytoskeleton • cell nucleus • cytoplasm • cytosol Biological process • apoptotic signaling pathway • regulation of NIK/NF-kappaB signaling • biological process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	55075	72565
Ensembl	ENSG00000137831	ENSMUSG00000034485
UniProt	Q9BZF9	Q8CGB3
RefSeq (mRNA)	NM_001008224 NM_018003	NM_028283 NM_001357407 NM_001357408
RefSeq (protein)	NP_001008225 NP_060473	NP_082559 NP_001344336 NP_001344337
Location (UCSC)	Chr 15: 70.65 – 70.76 Mb	Chr 9: 60.79 – 60.88 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000137831 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000034485 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Yamada K, Senju S, Nakatsura T, Murata Y, Ishihara M, Nakamura S, Ohno S, Negi A, Nishimura Y (Feb 2001). "Identification of a novel autoantigen UACA in patients with panuveitis". Biochem. Biophys. Res. Commun. 280 (4): 1169–76. doi:10.1006/bbrc.2001.4189. PMID 11162650.
6. Nagase T, Kikuno R, Nakayama M, Hirosawa M, Ohara O (Dec 2000). "Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (4): 273–81. doi:10.1093/dnares/7.4.271. PMID 10997877.
7. "Entrez Gene: UACA uveal autoantigen with coiled-coil domains and ankyrin repeats".

Further reading

• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Nakayama M, Kikuno R, Ohara O (2003). "Protein–Protein Interactions Between Large Proteins: Two-Hybrid Screening Using a Functionally Classified Library Composed of Long cDNAs". Genome Res. 12 (11): 1773–84. doi:10.1101/gr.406902. PMC 187542. PMID 12421765.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216.
• Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Ohkura T, Taniguchi S, Yamada K, et al. (2004). "Detection of the novel autoantibody (anti-UACA antibody) in patients with Graves' disease". Biochem. Biophys. Res. Commun. 321 (2): 432–40. doi:10.1016/j.bbrc.2004.06.162. PMID 15358194.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.