UBASH3A

Ubiquitin-associated and SH3 domain-containing protein A is a protein that in humans is encoded by the UBASH3A gene.[5][6]

UBASH3A
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2CRN
Identifiers
Aliases	UBASH3A, CLIP4, STS-2, TULA, TULA-1, ubiquitin associated and SH3 domain containing A
External IDs	OMIM: 605736 MGI: 1926074 HomoloGene: 56833 GeneCards: UBASH3A
Gene location (Human) Chr. Chromosome 21 (human)[1] Band 21q22.3 Start 42,403,447 bp[1] End 42,447,684 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17|17 A3.3 Start 31,207,873 bp[2] End 31,246,892 bp[2]
Gene ontology Molecular function • GO:0001948 protein binding • phosphatase activity Cellular component • cytoplasm • cytosol • extracellular exosome • cell nucleus • nucleoplasm • Golgi apparatus Biological process • regulation of cytokine production • negative regulation of T cell receptor signaling pathway • negative regulation of signal transduction • dephosphorylation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	53347	328795
Ensembl	ENSG00000160185	ENSMUSG00000042345
UniProt	P57075	Q3V3E1
RefSeq (mRNA)	NM_001001895 NM_001243467 NM_018961	NM_177823
RefSeq (protein)	NP_001001895 NP_001230396 NP_061834	NP_808491
Location (UCSC)	Chr 21: 42.4 – 42.45 Mb	Chr 17: 31.21 – 31.25 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000160185 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000042345 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Wattenhofer M, Shibuya K, Kudoh J, Lyle R, Michaud J, Rossier C, Kawasaki K, Asakawa S, Minoshima S, Berry A, Bonne-Tamir B, Shimizu N, Antonarakis SE, Scott HS (Apr 2001). "Isolation and characterization of the UBASH3A gene on 21q22.3 encoding a potential nuclear protein with a novel combination of domains". Hum Genet. 108 (2): 140–7. doi:10.1007/s004390000453. PMID 11281453. S2CID 22719211.
6. "Entrez Gene: UBASH3A ubiquitin associated and SH3 domain containing, A".

Further reading

• Smirnova EV, Collingwood TS, Bisbal C, et al. (2008). "TULA proteins bind to ABCE-1, a host factor of HIV-1 assembly, and inhibit HIV-1 biogenesis in a UBA-dependent fashion". Virology. 372 (1): 10–23. doi:10.1016/j.virol.2007.10.012. PMID 18006034.
• Collingwood TS, Smirnova EV, Bogush M, et al. (2007). "T-cell ubiquitin ligand affects cell death through a functional interaction with apoptosis-inducing factor, a key factor of caspase-independent apoptosis". J. Biol. Chem. 282 (42): 30920–8. doi:10.1074/jbc.M706870200. PMID 17709377.
• Bertelsen V, Breen K, Sandvig K, et al. (2007). "The Cbl-interacting protein TULA inhibits dynamin-dependent endocytosis". Exp. Cell Res. 313 (8): 1696–709. doi:10.1016/j.yexcr.2007.02.017. hdl:10852/28097. PMID 17382318.
• Hu YH, Warnatz HJ, Vanhecke D, et al. (2006). "Cell array-based intracellular localization screening reveals novel functional features of human chromosome 21 proteins". BMC Genomics. 7: 155. doi:10.1186/1471-2164-7-155. PMC 1526728. PMID 16780588.
• Hoeller D, Crosetto N, Blagoev B, et al. (2006). "Regulation of ubiquitin-binding proteins by monoubiquitination". Nat. Cell Biol. 8 (2): 163–9. doi:10.1038/ncb1354. PMID 16429130. S2CID 1324257.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Kowanetz K, Crosetto N, Haglund K, et al. (2004). "Suppressors of T-cell receptor signaling Sts-1 and Sts-2 bind to Cbl and inhibit endocytosis of receptor tyrosine kinases". J. Biol. Chem. 279 (31): 32786–95. doi:10.1074/jbc.M403759200. PMID 15159412.
• Feshchenko EA, Smirnova EV, Swaminathan G, et al. (2004). "TULA: an SH3- and UBA-containing protein that binds to c-Cbl and ubiquitin". Oncogene. 23 (27): 4690–706. doi:10.1038/sj.onc.1207627. PMID 15107835.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.