UBE3C

Ubiquitin-protein ligase E3C is an enzyme that in humans is encoded by the UBE3C gene.[5][6][7]

UBE3C
Identifiers
Aliases	UBE3C, HECTH2, ubiquitin protein ligase E3C
External IDs	OMIM: 614454 MGI: 2140998 HomoloGene: 8783 GeneCards: UBE3C
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7q36.3 Start 157,138,916 bp[1] End 157,269,370 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 B1 Start 29,569,242 bp[2] End 29,676,092 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding • ubiquitin-protein transferase activity • transferase activity • GO:1904264, GO:1904822, GO:0090622, GO:0090302 ubiquitin protein ligase activity • ubiquitin conjugating enzyme activity Cellular component • proteasome complex • intracellular • cell nucleus • cytoplasm Biological process • protein polyubiquitination • protein ubiquitination • ubiquitin-dependent protein catabolic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	9690	100763
Ensembl	ENSG00000009335	ENSMUSG00000039000
UniProt	Q15386	Q80U95
RefSeq (mRNA)	NM_014671	NM_133907
RefSeq (protein)	NP_055486	NP_598668
Location (UCSC)	Chr 7: 157.14 – 157.27 Mb	Chr 5: 29.57 – 29.68 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000009335 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000039000 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Nomura N, Miyajima N, Sazuka T, Tanaka A, Kawarabayasi Y, Sato S, Nagase T, Seki N, Ishikawa K, Tabata S (Dec 1995). "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1". DNA Res. 1 (1): 27–35. doi:10.1093/dnares/1.1.27. PMID 7584026.
6. You J, Pickart CM (Jun 2001). "A HECT domain E3 enzyme assembles novel polyubiquitin chains". J Biol Chem. 276 (23): 19871–8. doi:10.1074/jbc.M100034200. PMID 11278995.
7. "Entrez Gene: UBE3C ubiquitin protein ligase E3C".

Further reading

• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. Bibcode:2003Natur.424..157H. doi:10.1038/nature01782. PMID 12853948.
• You J, Wang M, Aoki T, et al. (2003). "Proteolytic targeting of transcriptional regulator TIP120B by a HECT domain E3 ligase". J. Biol. Chem. 278 (26): 23369–75. doi:10.1074/jbc.M212887200. PMID 12692129.
• Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology". Science. 300 (5620): 767–72. Bibcode:2003Sci...300..767S. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Nomura N, Miyajima N, Sazuka T, et al. (1995). "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1 (supplement)". DNA Res. 1 (1): 47–56. doi:10.1093/dnares/1.1.47. PMID 7584028.