UBE4A

Ubiquitin conjugation factor E4 A is a protein that in humans is encoded by the UBE4A gene.[5][6]

UBE4A
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1WGM
Identifiers
Aliases	UBE4A, E4, UBOX2, UFD2, ubiquitination factor E4A
External IDs	OMIM: 603753 MGI: 2154580 HomoloGene: 3517 GeneCards: UBE4A
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q23.3 Start 118,359,585 bp[1] End 118,399,211 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 A5.2 Start 44,923,127 bp[2] End 44,965,600 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • ubiquitin-protein transferase activity • GO:0001948 protein binding • transferase activity • ubiquitin-ubiquitin ligase activity Cellular component • ubiquitin ligase complex • cell nucleus • cytoplasm Biological process • protein ubiquitination • ubiquitin-dependent protein catabolic process • ubiquitin-dependent ERAD pathway • protein polyubiquitination Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	9354	140630
Ensembl	ENSG00000110344	ENSMUSG00000059890
UniProt	Q14139	E9Q735
RefSeq (mRNA)	NM_004788 NM_001204077	NM_145400 NM_001346698 NM_001361075 NM_001361076
RefSeq (protein)	NP_001191006 NP_004779	NP_001333627 NP_663375 NP_001348004 NP_001348005
Location (UCSC)	Chr 11: 118.36 – 118.4 Mb	Chr 9: 44.92 – 44.97 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation.

Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes an additional conjugation factor, E4, which is involved in multiubiquitin chain assembly.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000110344 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000059890 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Koegl M, Hoppe T, Schlenker S, Ulrich HD, Mayer TU, Jentsch S (Apr 1999). "A novel ubiquitination factor, E4, is involved in multiubiquitin chain assembly". Cell. 96 (5): 635–44. doi:10.1016/S0092-8674(00)80574-7. PMID 10089879.
6. "Entrez Gene: UBE4A ubiquitination factor E4A (UFD2 homolog, yeast)".

Further reading

• Robertson NG, Khetarpal U, Gutiérrez-Espeleta GA, et al. (1995). "Isolation of novel and known genes from a human fetal cochlear cDNA library using subtractive hybridization and differential screening". Genomics. 23 (1): 42–50. doi:10.1006/geno.1994.1457. PMID 7829101.
• Nagase T, Seki N, Tanaka A, et al. (1996). "Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 2 (4): 167–74, 199–210. doi:10.1093/dnares/2.4.167. PMID 8590280.
• Mahoney JA, Odin JA, White SM, et al. (2002). "The human homologue of the yeast polyubiquitination factor Ufd2p is cleaved by caspase 6 and granzyme B during apoptosis". Biochem. J. 361 (Pt 3): 587–95. doi:10.1042/0264-6021:3610587. PMC 1222341. PMID 11802788.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801. S2CID 23783563.
• Contino G, Amati F, Pucci S, et al. (2004). "Expression analysis of the gene encoding for the U-box-type ubiquitin ligase UBE4A in human tissues". Gene. 328: 69–74. doi:10.1016/j.gene.2003.11.017. PMID 15019985.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Spinette S, Lengauer C, Mahoney JA, et al. (2006). "Ufd2, a novel autoantigen in scleroderma, regulates sister chromatid separation". Cell Cycle. 3 (12): 1638–44. doi:10.4161/cc.3.12.1345. PMID 15611659.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.