UBP1

Upstream-binding protein 1 is a protein that in humans is encoded by the UBP1 gene.[5][6]

UBP1
Identifiers
Aliases	UBP1, LBP-1B, LBP-1a, LBP1A, LBP1B, upstream binding protein 1 (LBP-1a), upstream binding protein 1
External IDs	OMIM: 609784 MGI: 104889 HomoloGene: 8435 GeneCards: UBP1
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3p22.3 Start 33,388,336 bp[1] End 33,441,371 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 F3 Start 113,930,934 bp[2] End 113,977,202 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • DNA binding • GO:0001106 transcription corepressor activity • sequence-specific DNA binding • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component • cell nucleus • nucleoplasm • cytosol Biological process • viral replication • negative regulation of transcription, DNA-templated • regulation of transcription, DNA-templated • angiogenesis • transcription, DNA-templated • regulation of transcription from RNA polymerase II promoter Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	7342	22221
Ensembl	ENSG00000153560	ENSMUSG00000009741
UniProt	Q9NZI7	Q811S7
RefSeq (mRNA)	NM_001128160 NM_001128161 NM_014517	NM_001083319 NM_013699 NM_001372507 NM_001372508 NM_001372510 NM_001372511 NM_001372512 NM_001372514
RefSeq (protein)	NP_001121632 NP_001121633 NP_055332	NP_001076788 NP_038727 NP_001359436 NP_001359437 NP_001359439 NP_001359440 NP_001359441 NP_001359443
Location (UCSC)	Chr 3: 33.39 – 33.44 Mb	Chr 9: 113.93 – 113.98 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000153560 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000009741 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Yoon JB, Li G, Roeder RG (Mar 1994). "Characterization of a family of related cellular transcription factors which can modulate human immunodeficiency virus type 1 transcription in vitro". Mol Cell Biol. 14 (3): 1776–85. doi:10.1128/mcb.14.3.1776. PMC 358535. PMID 8114710.
6. "Entrez Gene: UBP1 upstream binding protein 1 (LBP-1a)".

Further reading

• Kato H, Horikoshi M, Roeder RG (1991). "Repression of HIV-1 transcription by a cellular protein". Science. 251 (5000): 1476–9. doi:10.1126/science.2006421. PMID 2006421.
• Parada CA, Yoon JB, Roeder RG (1995). "A novel LBP-1-mediated restriction of HIV-1 transcription at the level of elongation in vitro". J. Biol. Chem. 270 (5): 2274–83. doi:10.1074/jbc.270.5.2274. PMID 7836461.
• Huang N, Miller WL (2000). "Cloning of factors related to HIV-inducible LBP proteins that regulate steroidogenic factor-1-independent human placental transcription of the cholesterol side-chain cleavage enzyme, P450scc". J. Biol. Chem. 275 (4): 2852–8. doi:10.1074/jbc.275.4.2852. PMID 10644752.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Zhao H, Li J, Jiang L (2004). "Inhibition of HIV-1 TAR RNA-Tat peptide complexation using poly(acrylic acid)". Biochem. Biophys. Res. Commun. 320 (1): 95–9. doi:10.1016/j.bbrc.2004.05.148. PMID 15207707.
• Huang N, Miller WL (2005). "LBP proteins modulate SF1-independent expression of P450scc in human placental JEG-3 cells". Mol. Endocrinol. 19 (2): 409–20. doi:10.1210/me.2004-0086. PMID 15471945.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.