UDP-glucuronate 5'-epimerase
In enzymology, an UDP-glucuronate 5'-epimerase (EC 5.1.3.12) is an enzyme that catalyzes the chemical reaction
- UDP-glucuronate UDP-L-iduronate
| UDP-glucuronate 5'-epimerase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 5.1.3.12 | ||||||||
| CAS number | 37318-38-0 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Hence, this enzyme has one substrate, UDP-glucuronate, and one product, UDP-L-iduronate.
This enzyme belongs to the family of isomerases, specifically those racemases and epimerases acting on carbohydrates and derivatives. The systematic name of this enzyme class is UDP-glucuronate 5'-epimerase. Other names in common use include uridine diphosphoglucuronate 5'-epimerase, UDP-glucuronic acid 5'-epimerase, and C-5-uronosyl epimerase. This enzyme participates in nucleotide sugars metabolism. It employs one cofactor, NAD+.
References
- Jacobson B, Davidson EA (March 1962). "Biosynthesis of uronic acids by skin enzymes. I. Uridine diphosphate-D-glucuronic acid-5-epimerase". The Journal of Biological Chemistry. 237: 638–42. PMID 14450717.
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