UFSP2

UFM1 specific peptidase 2 is a protein that in humans is encoded by the UFSP2 gene. [5]

UFSP2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3OQC
Identifiers
Aliases	UFSP2, C4orf20, BHD, UFM1-specific peptidase 2, UFM1 specific peptidase 2, SEMDDR
External IDs	OMIM: 611482 MGI: 1913679 HomoloGene: 10151 GeneCards: UFSP2
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4q35.1 Start 185,399,537 bp[1] End 185,425,979 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8|8 B1.1 Start 45,975,528 bp[2] End 45,996,958 bp[2]
Gene ontology Molecular function • peptidase activity • hydrolase activity • cysteine-type peptidase activity • GO:0001948 protein binding • thiolester hydrolase activity • UFM1 hydrolase activity Cellular component • cell nucleus • cytoplasm • endoplasmic reticulum Biological process • regulation of intracellular estrogen receptor signaling pathway • proteolysis Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	55325	192169
Ensembl	ENSG00000109775	ENSMUSG00000031634
UniProt	Q9NUQ7	Q99K23
RefSeq (mRNA)	NM_018359	NM_138668
RefSeq (protein)	NP_060829	NP_619609
Location (UCSC)	Chr 4: 185.4 – 185.43 Mb	Chr 8: 45.98 – 46 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene encodes a highly conserved cysteine protease. The protein cleaves two C-terminal residues from ubiquitin-fold modifier 1, a ubiquitin-like post-translational modifier protein. Activation of ubiquitin-fold modifier 1 by the encoded protein exposes a C-terminal glycine residue that allows interaction with other proteins and transfer to its target protein. An allelic variant of this gene has been associated with Beukes hip dysplasia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016].

References

1. GRCh38: Ensembl release 89: ENSG00000109775 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000031634 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: UFM1 specific peptidase 2". Retrieved 2020-04-15.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.