USP19

Ubiquitin specific peptidase 19 is a protein that in humans is encoded by the USP19 gene. [5]

USP19
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1WH0, 4X3G
Identifiers
Aliases	USP19, ZMYND9, ubiquitin specific peptidase 19
External IDs	OMIM: 614471 MGI: 1918722 HomoloGene: 41730 GeneCards: USP19
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3p21.31 Start 49,108,046 bp[1] End 49,120,938 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 F2 Start 108,490,602 bp[2] End 108,502,337 bp[2]
Gene ontology Molecular function • Hsp90 protein binding • cysteine-type peptidase activity • metal ion binding • Lys48-specific deubiquitinase activity • peptidase activity • GO:0001948 protein binding • thiol-dependent ubiquitin-specific protease activity • hydrolase activity • ubiquitin protein ligase binding Cellular component • integral component of membrane • endoplasmic reticulum membrane • membrane • endoplasmic reticulum • cytosol • cell nucleus Biological process • protein K48-linked deubiquitination • regulation of protein stability • ubiquitin-dependent protein catabolic process • protein stabilization • response to endoplasmic reticulum stress • proteolysis • regulation of ERAD pathway • regulation of cellular response to hypoxia • negative regulation of skeletal muscle tissue development • positive regulation of cell cycle process • ubiquitin-dependent ERAD pathway • negative regulation of proteasomal protein catabolic process • protein deubiquitination Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10869	71472
Ensembl	ENSG00000172046	ENSMUSG00000006676
UniProt	O94966	Q3UJD6
RefSeq (mRNA)	NM_001199160 NM_001199161 NM_001199162 NM_006677 NM_001351098 NM_001351099 NM_001351100 NM_001351101 NM_001351102 NM_001351103 NM_001351104 NM_001351105 NM_001351106 NM_001351107 NM_001351108	NM_001168371 NM_001168372 NM_001168373 NM_027804 NM_145407
RefSeq (protein)	NP_001186089 NP_001186090 NP_001186091 NP_006668 NP_001338027 NP_001338028 NP_001338029 NP_001338030 NP_001338031 NP_001338032 NP_001338033 NP_001338034 NP_001338035 NP_001338036 NP_001338037	NP_001161843 NP_001161844 NP_001161845 NP_082080 NP_663382
Location (UCSC)	Chr 3: 49.11 – 49.12 Mb	Chr 9: 108.49 – 108.5 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000172046 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000006676 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Ubiquitin specific peptidase 19". Retrieved 2016-02-18.

External links

• PDBe-KB provides an overview of all the structure information available in the PDB for Human Ubiquitin carboxyl-terminal hydrolase 19 (USP19)

Further reading