USP33

Ubiquitin carboxyl-terminal hydrolase 33 is an enzyme that in humans is encoded by the USP33 gene.[5][6]

USP33
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2UZG
Identifiers
Aliases	USP33, VDU1, ubiquitin specific peptidase 33
External IDs	OMIM: 615146 MGI: 2159711 HomoloGene: 8996 GeneCards: USP33
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p31.1 Start 77,695,987 bp[1] End 77,759,852 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 H3 Start 152,346,478 bp[2] End 152,393,617 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • cysteine-type peptidase activity • Ral GTPase binding • zinc ion binding • metal ion binding • peptidase activity • ubiquitin binding • GO:0001948 protein binding • thiol-dependent ubiquitin-specific protease activity • cysteine-type endopeptidase activity • hydrolase activity • G-protein coupled receptor binding Cellular component • cytoplasm • cell body • centrosome • Golgi apparatus • VCB complex • focal adhesion • nucleoplasm • microtubule organizing center • autophagosome • perinuclear region of cytoplasm • cytoskeleton • cytosol Biological process • endocytosis • protein K48-linked deubiquitination • ubiquitin-dependent protein catabolic process • regulation of G-protein coupled receptor protein signaling pathway • centrosome duplication • cellular response to starvation • protein stabilization • negative regulation of protein binding • proteolysis • axon guidance • regulation of autophagy • protein K63-linked deubiquitination • positive regulation of protein binding • cell migration • protein deubiquitination Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	23032	170822
Ensembl	ENSG00000077254	ENSMUSG00000025437
UniProt	Q8TEY7	Q8R5K2
RefSeq (mRNA)	NM_015017 NM_201624 NM_201626	NM_001076676 NM_001252486 NM_133247 NM_001355666
RefSeq (protein)	NP_055832 NP_963918 NP_963920 NP_001364359 NP_001364360 NP_001364361 NP_001364362 NP_001364363 NP_001364364 NP_001364365 NP_001364366 NP_001364367 NP_001364368	NP_001070144 NP_001239415 NP_573510 NP_001342595
Location (UCSC)	Chr 1: 77.7 – 77.76 Mb	Chr 3: 152.35 – 152.39 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

USP33 has been shown to interact with DIO2,[7] SELENBP1[8] and Von Hippel–Lindau tumor suppressor.[9]

References

1. GRCh38: Ensembl release 89: ENSG00000077254 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000025437 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Puente XS, Sánchez LM, Overall CM, López-Otín C (Jul 2003). "Human and mouse proteases: a comparative genomic approach". Nat Rev Genet. 4 (7): 544–558. doi:10.1038/nrg1111. PMID 12838346. S2CID 2856065.
6. "Entrez Gene: USP33 ubiquitin specific peptidase 33".
7. Curcio-Morelli C, Zavacki AM, Christofollete M, Gereben B, de Freitas BC, Harney JW, Li Z, Wu G, Bianco AC (Jul 2003). "Deubiquitination of type 2 iodothyronine deiodinase by von Hippel-Lindau protein-interacting deubiquitinating enzymes regulates thyroid hormone activation". J. Clin. Invest. 112 (2): 189–196. doi:10.1172/JCI18348. PMC 164294. PMID 12865408.
8. Jeong JY, Wang Y, Sytkowski AJ (Feb 2009). "Human selenium binding protein-1 (hSP56) interacts with VDU1 in a selenium-dependent manner". Biochem. Biophys. Res. Commun. 379 (2): 583–588. doi:10.1016/j.bbrc.2008.12.110. PMID 19118533.
9. Li Z, Na X, Wang D, Schoen SR, Messing EM, Wu G (Feb 2002). "Ubiquitination of a novel deubiquitinating enzyme requires direct binding to von Hippel-Lindau tumor suppressor protein". J. Biol. Chem. 277 (7): 4656–4662. doi:10.1074/jbc.M108269200. PMID 11739384.

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–174. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–156. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Kikuno R, Nagase T, Ishikawa K, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (1999). "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (3): 197–205. doi:10.1093/dnares/6.3.197. PMID 10470851.
• Li Z, Na X, Wang D, Schoen SR, Messing EM, Wu G (2002). "Ubiquitination of a novel deubiquitinating enzyme requires direct binding to von Hippel-Lindau tumor suppressor protein". J. Biol. Chem. 277 (7): 4656–4662. doi:10.1074/jbc.M108269200. PMID 11739384.
• Li Z, Wang D, Na X, Schoen SR, Messing EM, Wu G (2002). "Identification of a deubiquitinating enzyme subfamily as substrates of the von Hippel-Lindau tumor suppressor". Biochem. Biophys. Res. Commun. 294 (3): 700–709. doi:10.1016/S0006-291X(02)00534-X. PMID 12056827.
• Curcio-Morelli C, Zavacki AM, Christofollete M, Gereben B, de Freitas BC, Harney JW, Li Z, Wu G, Bianco AC (2003). "Deubiquitination of type 2 iodothyronine deiodinase by von Hippel-Lindau protein-interacting deubiquitinating enzymes regulates thyroid hormone activation". J. Clin. Invest. 112 (2): 189–196. doi:10.1172/JCI18348. PMC 164294. PMID 12865408.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–1178. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Allen MD, Bycroft M (2007). "The solution structure of the ZnF UBP domain of USP33/VDU1". Protein Sci. 16 (9): 2072–2075. doi:10.1110/ps.072967807. PMC 2206988. PMID 17766394.