USP47

Ubiquitin carboxyl-terminal hydrolase 47 is an enzyme that in humans is encoded by the USP47 gene.[5][6]

USP47
Identifiers
Aliases	USP47, TRFP, ubiquitin specific peptidase 47
External IDs	OMIM: 614460 MGI: 1922246 HomoloGene: 9929 GeneCards: USP47
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11p15.3 Start 11,841,423 bp[1] End 11,959,323 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 F1 Start 112,023,504 bp[2] End 112,111,661 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • WD40-repeat domain binding • peptidase activity • hydrolase activity • cysteine-type peptidase activity • thiol-dependent ubiquitin-specific protease activity • GO:0001948 protein binding • GO:1904265 ubiquitinyl hydrolase activity • cysteine-type endopeptidase activity Cellular component • cytoplasm • SCF ubiquitin ligase complex • nucleoplasm • cytosol Biological process • ubiquitin-dependent protein catabolic process • proteolysis • negative regulation of apoptotic process • cellular response to UV • negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage • DNA repair • positive regulation of cell growth • monoubiquitinated protein deubiquitination • base-excision repair • negative regulation of G2/M transition of mitotic cell cycle • response to drug • negative regulation of transcription, DNA-templated • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process • cellular response to DNA damage stimulus • protein deubiquitination • positive regulation of canonical Wnt signaling pathway • regulation of protein stability Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	55031	74996
Ensembl	ENSG00000170242	ENSMUSG00000059263
UniProt	Q96K76	Q8BY87
RefSeq (mRNA)	NM_001282659 NM_017944 NM_001330208	NM_133758 NM_177249 NM_001357952
RefSeq (protein)	NP_001269588 NP_001317137 NP_060414 NP_001359020 NP_001359021 NP_001359022 NP_001359023 NP_001359024 NP_001359025 NP_001359026 NP_001359027 NP_001359028 NP_001359029 NP_001359030 NP_001359031 NP_001359032	NP_598519 NP_796223 NP_001344881
Location (UCSC)	Chr 11: 11.84 – 11.96 Mb	Chr 7: 112.02 – 112.11 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000170242 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000059263 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Puente XS, Sanchez LM, Overall CM, Lopez-Otin C (Jul 2003). "Human and mouse proteases: a comparative genomic approach". Nat Rev Genet. 4 (7): 544–58. doi:10.1038/nrg1111. PMID 12838346. S2CID 2856065.
6. "Entrez Gene: USP47 ubiquitin specific peptidase 47".

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Sato S, Tomomori-Sato C, Banks CA, et al. (2003). "Identification of mammalian Mediator subunits with similarities to yeast Mediator subunits Srb5, Srb6, Med11, and Rox3". J. Biol. Chem. 278 (17): 15123–7. doi:10.1074/jbc.C300054200. PMID 12584197.
• Sato S, Tomomori-Sato C, Banks CA, et al. (2004). "A mammalian homolog of Drosophila melanogaster transcriptional coactivator intersex is a subunit of the mammalian Mediator complex". J. Biol. Chem. 278 (50): 49671–4. doi:10.1074/jbc.C300444200. PMID 14576168.
• Tomomori-Sato C, Sato S, Parmely TJ, et al. (2004). "A mammalian mediator subunit that shares properties with Saccharomyces cerevisiae mediator subunit Cse2". J. Biol. Chem. 279 (7): 5846–51. doi:10.1074/jbc.M312523200. PMID 14638676.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Quesada V, Díaz-Perales A, Gutiérrez-Fernández A, et al. (2004). "Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases". Biochem. Biophys. Res. Commun. 314 (1): 54–62. doi:10.1016/j.bbrc.2003.12.050. PMID 14715245.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.