UTF1

Undifferentiated embryonic cell transcription factor 1 is a protein in humans that is encoded by the UTF1 gene. [5] UTF1, first reported in 1998, is expressed in pluripotent cells including embryonic stem cells and embryonic carcinoma cells.[6] Its expression is rapidly reduced upon differentiation. UTF1 protein is localized to the cell nucleus, where it functions to regulate the pluripotent chromatin state and buffer mRNA levels by promoting degradation of mRNA.[7]

UTF1
Identifiers
Aliases	UTF1, undifferentiated embryonic cell transcription factor 1
External IDs	OMIM: 604130 MGI: 1276125 HomoloGene: 48226 GeneCards: UTF1
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10q26.3 Start 133,230,217 bp[1] End 133,231,558 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 F4 Start 139,943,789 bp[2] End 139,945,112 bp[2]
Gene ontology Molecular function • GO:0001105 transcription coactivator activity • HMG box domain binding • GO:0001948 protein binding Cellular component • cell nucleus Biological process • regulation of transcription from RNA polymerase II promoter • male gonad development • regulation of transcription, DNA-templated • transcription, DNA-templated • positive regulation of transcription from RNA polymerase II promoter Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	8433	22286
Ensembl	ENSG00000171794	ENSMUSG00000047751
UniProt	Q5T230	Q6J1H4
RefSeq (mRNA)	NM_003577	NM_009482
RefSeq (protein)	NP_003568	NP_033508
Location (UCSC)	Chr 10: 133.23 – 133.23 Mb	Chr 7: 139.94 – 139.95 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Aberrant expression of UTF1 has also been reported in cervical cancer cells, where the UTF1 gene promoter loses methylation and becomes abnormally expressed compared to normal cervical cells.[8]

References

1. GRCh38: Ensembl release 89: ENSG00000171794 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000047751 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Undifferentiated embryonic cell transcription factor 1". Retrieved 2013-05-30.
6. Okuda A; Fukushima A; Nishimoto M; Orimo A; Yamagishi T; Nabeshima Y; Kuro-o M; Nabeshima Yi; Boon K; Keaveney M; Stunnenberg HG; Muramatsu M. (April 1998). "UTF1, a novel transcriptional coactivator expressed in pluripotent embryonic stem cells and extra-embryonic cells". EMBO J. 17 (7): 2019–32. doi:10.1093/emboj/17.7.2019. PMC 1170547. PMID 9524124.
7. Jia J, Zheng X, Hu G, Cui K, Zhang J, Zhang A, Jiang H, Lu B, Yates J, Liu C, Zhao K, Zheng Y (October 2012). "Regulation of pluripotency and self- renewal of ESCs through epigenetic-threshold modulation and mRNA pruning". Cell. 151 (3): 576–89. doi:10.1016/j.cell.2012.09.023. PMC 3575637. PMID 23101626.
8. Guenin S, Mouallif M, Deplus R, Lampe X, Krusy N, Calonne E, Delbecque K, Kridelka F, Fuks F, Ennaji MM, Delvenne P (August 2012). "Aberrant promoter methylation and expression of UTF1 during cervical carcinogenesis". PLOS ONE. 7 (8): e42704. doi:10.1371/journal.pone.0042704. PMC 3411846. PMID 22880087.

Further reading