UTP20

Small subunit processome component 20 homolog is a protein that in humans is encoded by the UTP20 gene.[5][6][7][8]

UTP20
Identifiers
Aliases	UTP20, DRIM, 1A6/DRIM, small subunit processome component, UTP20 small subunit processome component
External IDs	OMIM: 612822 MGI: 1917933 HomoloGene: 38373 GeneCards: UTP20
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q23.2 Start 101,280,105 bp[1] End 101,386,618 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10|10 C1 Start 88,746,607 bp[2] End 88,826,804 bp[2]
Gene ontology Molecular function • GO:0001948 protein binding • RNA binding Cellular component • cytoplasm • preribosome, small subunit precursor • small-subunit processome • nucleolus • cell nucleus • 90S preribosome • nucleoplasm • cell membrane Biological process • endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) • endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) • endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) • negative regulation of cell proliferation • maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) • rRNA processing Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	27340	70683
Ensembl	ENSG00000120800	ENSMUSG00000004356
UniProt	O75691	Q5XG71
RefSeq (mRNA)	NM_014503	NM_175158
RefSeq (protein)	NP_055318	NP_780367
Location (UCSC)	Chr 12: 101.28 – 101.39 Mb	Chr 10: 88.75 – 88.83 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000120800 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000004356 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Schwirzke M, Gnirke A, Bork P, Tarin D, Weidle UH (Aug 1998). "Differential gene expression in mammary carcinoma cell lines: identification of DRIM, a new gene down-regulated in metastasis". Anticancer Res. 18 (3A): 1409–21. PMID 9673349.
6. Bernstein KA, Gallagher JE, Mitchell BM, Granneman S, Baserga SJ (Dec 2004). "The small-subunit processome is a ribosome assembly intermediate". Eukaryot Cell. 3 (6): 1619–26. doi:10.1128/EC.3.6.1619-1626.2004. PMC 539036. PMID 15590835.
7. Peng WT, Robinson MD, Mnaimneh S, Krogan NJ, Cagney G, Morris Q, Davierwala AP, Grigull J, Yang X, Zhang W, Mitsakakis N, Ryan OW, Datta N, Jojic V, Pal C, Canadien V, Richards D, Beattie B, Wu LF, Altschuler SJ, Roweis S, Frey BJ, Emili A, Greenblatt JF, Hughes TR (Jul 2003). "A panoramic view of yeast noncoding RNA processing". Cell. 113 (7): 919–33. doi:10.1016/S0092-8674(03)00466-5. PMID 12837249. S2CID 10190539.
8. "Entrez Gene: UTP20 UTP20, small subunit (SSU) processome component, homolog (yeast)".

Further reading

• Adams MD, Kerlavage AR, Fleischmann RD, Fuldner RA, Bult CJ, Lee NH, Kirkness EF, Weinstock KG, Gocayne JD, White O (1995). "Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence" (PDF). Nature. 377 (6547 Suppl): 3–174. PMID 7566098.
• Andersen JS, Lyon CE, Fox AH, Leung AK, Lam YW, Steen H, Mann M, Lamond AI (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298. S2CID 14132033.
• Scherl A, Couté Y, Déon C, Callé A, Kindbeiter K, Sanchez JC, Greco A, Hochstrasser D, Diaz JJ (2003). "Functional proteomic analysis of human nucleolus". Mol. Biol. Cell. 13 (11): 4100–9. doi:10.1091/mbc.E02-05-0271. PMC 133617. PMID 12429849.
• Goodison S, Viars C, Grazzini M, Urquidi V (2004). "The interrelationship between DRIM gene expression and cytogenetic and phenotypic characteristics in human breast tumor cell lines". BMC Genomics. 4 (1): 39. doi:10.1186/1471-2164-4-39. PMC 222913. PMID 14503924.
• Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Andersen JS, Lam YW, Leung AK, Ong SE, Lyon CE, Lamond AI, Mann M (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.
• Xing X, Du X, Lu Z, Ning T, Su X, Ke Y (2005). "Characterization of the promoter of 1A6/DRIM, a novel cancer-related gene and identification of its transcriptional activator". Gene. 344: 161–9. doi:10.1016/j.gene.2004.09.036. PMID 15656982.
• Yang L, Zhao J, Lü W, Li Y, Du X, Ning T, Lu G, Ke Y (2006). "KIAA0649, a 1A6/DRIM-interacting protein with the oncogenic potential". Biochem. Biophys. Res. Commun. 334 (3): 884–90. doi:10.1016/j.bbrc.2005.06.179. PMID 16053918.
• Liu J, Du X, Ke Y (2006). "Mapping nucleolar localization sequences of 1A6/DRIM". FEBS Lett. 580 (5): 1405–10. doi:10.1016/j.febslet.2006.01.064. PMID 16458307. S2CID 29337295.
• Nousiainen M, Silljé HH, Sauer G, Nigg EA, Körner R (2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.
• Wang Y, Liu J, Zhao H, Lü W, Zhao J, Yang L, Li N, Du X, Ke Y (2007). "Human 1A6/DRIM, the homolog of yeast Utp20, functions in the 18S rRNA processing". Biochim. Biophys. Acta. 1773 (6): 863–8. doi:10.1016/j.bbamcr.2007.04.002. PMID 17498821.