UTY (gene)

Histone demethylase UTY is an enzyme that in humans is encoded by the UTY gene.[3][4][5]

UTY
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 3ZLI, 3ZPO, 4UF0, 5FY0, 5FXW, 5FXX, 5FXZ, 5FY1, 5FY7, 5FYM, 5FXV, 5A1L
Identifiers
Aliases	UTY, KDM6AL, UTY1, ubiquitously transcribed tetratricopeptide repeat containing, Y-linked, KDM6C
External IDs	OMIM: 400009 GeneCards: UTY
Gene location (Human) Chr. Y chromosome (human)[1] Band Yq11.221 Start 13,248,379 bp[1] End 13,480,673 bp[1]
RNA expression pattern More reference expression data
Gene ontology Molecular function • oxidoreductase activity • dioxygenase activity • histone demethylase activity (H3-K27 specific) • metal ion binding • histone demethylase activity • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • chromatin binding • chromatin DNA binding • sequence-specific DNA binding Cellular component • cell nucleus • nucleoplasm • MLL3/4 complex Biological process • regulation of gene expression • oxidation-reduction process • histone H3-K27 demethylation • chromatin organization Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	7404	n/a
Ensembl	ENSG00000183878	n/a
UniProt	O14607	n/a
RefSeq (mRNA)	NM_001258249 NM_001258250 NM_001258251 NM_001258252 NM_001258253 NM_001258254 NM_001258255 NM_001258256 NM_001258257 NM_001258258 NM_001258259 NM_001258260 NM_001258261 NM_001258262 NM_001258263 NM_001258264 NM_001258265 NM_001258266 NM_001258267 NM_001258268 NM_001258269 NM_001258270 NM_007125 NM_182659 NM_182660	n/a
RefSeq (protein)	NP_001245178 NP_001245179 NP_001245180 NP_001245181 NP_001245182 NP_001245183 NP_001245184 NP_001245185 NP_001245186 NP_001245187 NP_001245188 NP_001245189 NP_001245190 NP_001245191 NP_001245192 NP_001245193 NP_001245194 NP_001245195 NP_001245196 NP_001245197 NP_001245198 NP_001245199 NP_009056 NP_872600 NP_872601 NP_001245196.1 NP_001245192.1 NP_001245178.1 NP_001245194.1 NP_001245186.1 NP_001245191.1 NP_001245187.1	n/a
Location (UCSC)	Chr Y: 13.25 – 13.48 Mb	n/a
PubMed search	[2]	n/a
Wikidata
View/Edit Human

This gene encodes a protein containing tetratricopeptide repeats which are thought to be involved in protein–protein interactions. This protein is a minor histocompatibility antigen which may induce graft rejection of male stem cell grafts. Alternative splicing results in multiple transcript variants encoding different isoforms.[5]

Interactions

UTY has been shown to interact with TLE1[6] and WDR90.[7]

References

1. GRCh38: Ensembl release 89: ENSG00000183878 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. Greenfield A, Scott D, Pennisi D, Ehrmann I, Ellis P, Cooper L, et al. (December 1996). "An H-YDb epitope is encoded by a novel mouse Y chromosome gene". Nature Genetics. 14 (4): 474–8. doi:10.1038/ng1296-474. PMID 8944031.
4. Greenfield A, Carrel L, Pennisi D, Philippe C, Quaderi N, Siggers P, et al. (April 1998). "The UTX gene escapes X inactivation in mice and humans". Human Molecular Genetics. 7 (4): 737–42. doi:10.1093/hmg/7.4.737. PMID 9499428.
5. "Entrez Gene: UTY ubiquitously transcribed tetratricopeptide repeat gene, Y-linked".
6. Grbavec D, Lo R, Liu Y, Greenfield A, Stifani S (January 1999). "Groucho/transducin-like enhancer of split (TLE) family members interact with the yeast transcriptional co-repressor SSN6 and mammalian SSN6-related proteins: implications for evolutionary conservation of transcription repression mechanisms". The Biochemical Journal. 337 ( Pt 1) (1): 13–7. doi:10.1042/0264-6021:3370013. PMC 1219929. PMID 9854018.
7. "STRING: functional protein association networks". string-db.org. Retrieved 2015-05-07.

Further reading

• Lahn BT, Page DC (October 1997). "Functional coherence of the human Y chromosome". Science. 278 (5338): 675–80. Bibcode:1997Sci...278..675L. doi:10.1126/science.278.5338.675. PMID 9381176.
• Grbavec D, Lo R, Liu Y, Greenfield A, Stifani S (January 1999). "Groucho/transducin-like enhancer of split (TLE) family members interact with the yeast transcriptional co-repressor SSN6 and mammalian SSN6-related proteins: implications for evolutionary conservation of transcription repression mechanisms". The Biochemical Journal. 337 ( Pt 1) (1): 13–7. doi:10.1042/0264-6021:3370013. PMC 1219929. PMID 9854018.
• Warren EH, Gavin MA, Simpson E, Chandler P, Page DC, Disteche C, et al. (March 2000). "The human UTY gene encodes a novel HLA-B8-restricted H-Y antigen". Journal of Immunology. 164 (5): 2807–14. doi:10.4049/jimmunol.164.5.2807. PMID 10679124.
• Foresta C, Ferlin A, Moro E (May 2000). "Deletion and expression analysis of AZFa genes on the human Y chromosome revealed a major role for DBY in male infertility". Human Molecular Genetics. 9 (8): 1161–9. doi:10.1093/hmg/9.8.1161. PMID 10767340.
• Shen P, Wang F, Underhill PA, Franco C, Yang WH, Roxas A, et al. (June 2000). "Population genetic implications from sequence variation in four Y chromosome genes". Proceedings of the National Academy of Sciences of the United States of America. 97 (13): 7354–9. Bibcode:2000PNAS...97.7354S. doi:10.1073/pnas.97.13.7354. PMC 16549. PMID 10861003.
• Vogt MH, Goulmy E, Kloosterboer FM, Blokland E, de Paus RA, Willemze R, Falkenburg JH (November 2000). "UTY gene codes for an HLA-B60-restricted human male-specific minor histocompatibility antigen involved in stem cell graft rejection: characterization of the critical polymorphic amino acid residues for T-cell recognition". Blood. 96 (9): 3126–32. PMID 11049993.
• Gevaert K, Goethals M, Martens L, Van Damme J, Staes A, Thomas GR, Vandekerckhove J (May 2003). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nature Biotechnology. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801.
• Agate RJ, Choe M, Arnold AP (February 2004). "Sex differences in structure and expression of the sex chromosome genes CHD1Z and CHD1W in zebra finches". Molecular Biology and Evolution. 21 (2): 384–96. doi:10.1093/molbev/msh027. PMID 14660691.
• Gerrard DT, Filatov DA (June 2005). "Positive and negative selection on mammalian Y chromosomes". Molecular Biology and Evolution. 22 (6): 1423–32. doi:10.1093/molbev/msi128. PMID 15758204.