VCX

Variable charge X-linked protein 1 is a protein that in humans is encoded by the VCX gene.[3][4][5]

VCX
Identifiers
Aliases	VCX, VCX-10r, VCX-B1, VCX1, VCX10R, VCXB1, variable charge, X-linked, variable charge X-linked
External IDs	OMIM: 300229 HomoloGene: 88395 GeneCards: VCX
Gene location (Human) Chr. X chromosome (human)[1] Band Xp22.31 Start 7,842,262 bp[1] End 7,844,143 bp[1]
RNA expression pattern More reference expression data
Gene ontology Molecular function • chromatin binding Cellular component • nucleolus • cell nucleus Biological process • ribosome assembly • chromatin organization • spermatogenesis • brain development Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	26609	n/a
Ensembl	ENSG00000182583	n/a
UniProt	Q9H320	n/a
RefSeq (mRNA)	NM_013452	n/a
RefSeq (protein)	NP_038480	n/a
Location (UCSC)	Chr X: 7.84 – 7.84 Mb	n/a
PubMed search	[2]	n/a
Wikidata
View/Edit Human

This gene belongs to the VCX/Y gene family, which has multiple members on both X and Y chromosomes, and all are expressed exclusively in male germ cells. The X-linked members are clustered on chromosome Xp22 and Y-linked members are two identical copies of the gene within a palindromic region on Yq11. The family members share a high degree of sequence identity, with the exception that a 30-bp unit is tandemly repeated in X-linked members but occurs only once in Y-linked members. The VCX gene cluster is polymorphic in terms of copy number; different individuals may have a different number of VCX genes. VCX/Y genes encode small and highly charged proteins of unknown function. The presence of a putative bipartite nuclear localization signal suggests that VCX/Y members are nuclear proteins. This gene contains 10 repeats of the 30-bp unit.[5]

References

1. GRCh38: Ensembl release 89: ENSG00000182583 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. Lahn BT, Page DC (Feb 2000). "A human sex-chromosomal gene family expressed in male germ cells and encoding variably charged proteins". Hum Mol Genet. 9 (2): 311–9. doi:10.1093/hmg/9.2.311. PMID 10607842.
4. Fukami M, Kirsch S, Schiller S, Richter A, Benes V, Franco B, Muroya K, Rao E, Merker S, Niesler B, Ballabio A, Ansorge W, Ogata T, Rappold GA (Sep 2000). "A Member of a Gene Family on Xp22.3, VCX-A, Is Deleted in Patients with X-Linked Nonspecific Mental Retardation". Am J Hum Genet. 67 (3): 563–73. doi:10.1086/303047. PMC 1287516. PMID 10903929.
5. "Entrez Gene: VCX variable charge, X-linked".

Further reading

• Zou SW, Zhang JC, Zhang XD, et al. (2004). "Expression and localization of VCX/Y proteins and their possible involvement in regulation of ribosome assembly during spermatogenesis". Cell Res. 13 (3): 171–7. doi:10.1038/sj.cr.7290161. PMID 12862317.
• Sy SM, Wong N, Mok TS, et al. (2003). "Genetic alterations of lung adenocarcinoma in relation to smoking and ethnicity". Lung Cancer. 41 (1): 91–9. doi:10.1016/S0169-5002(03)00138-7. PMID 12826317.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.