VPREB3

Pre-B lymphocyte protein 3 is a protein that in humans is encoded by the VPREB3 gene.[5][6][7][8]

VPREB3
Identifiers
Aliases	VPREB3, 8HS20, N27C7-2, pre-B lymphocyte 3, V-set pre-B cell surrogate light chain 3
External IDs	OMIM: 605017 MGI: 98938 HomoloGene: 7598 GeneCards: VPREB3
Gene location (Human) Chr. Chromosome 22 (human)[1] Band 22q11.23|22q11 Start 23,752,743 bp[1] End 23,754,425 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10|10 C1 Start 75,943,057 bp[2] End 75,949,657 bp[2]
RNA expression pattern More reference expression data
Orthologs
Species	Human	Mouse
Entrez	29802	22364
Ensembl	ENSG00000128218	ENSMUSG00000000903
UniProt	Q9UKI3	n/a
RefSeq (mRNA)	NM_013378	NM_009514 NM_001358532
RefSeq (protein)	NP_037510	n/a
Location (UCSC)	Chr 22: 23.75 – 23.75 Mb	Chr 10: 75.94 – 75.95 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

The VPREB3 gene product is the human homologue of the mouse VpreB3 (8HS20) protein, and is specifically expressed in cell lines representative of all stages of B-lymphocyte differentiation. It is also related to VPREB1 and other members of the immunoglobulin supergene family. The VPREB3 protein apparently associates with membrane mu heavy chains early in the course of pre-B cell receptor biosynthesis. The precise function of VPREB3 is not known, but it may contribute to mu chain transport in pre-B cells.[6][8] In humans, besides the bone marrow and secondary lymphoid tissues such as the tonsils, the VPREB3 protein is also present in Purkinje cells of the cerebellum and in the zona glomerulosa of the adrenal.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000128218 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000000903 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Rosnet O, Mattei MG, Delattre O, Schiff C (Apr 2000). "VPREB3: cDNA characterization and expression in human and chromosome mapping in human and mouse". Cytogenet Cell Genet. 87 (3–4): 205–8. doi:10.1159/000015468. PMID 10702669.
6. Felizola SJ, Katsu K, Ise K, Nakamura Y, Arai Y, Satoh F, Sasano H (2015). "Pre-B lymphocyte protein 3 (VPREB3) expression in the adrenal cortex: precedent for non-immunological roles in normal and neoplastic human tissues". Endocrine Pathology. [in press].
7. Rosnet O, Blanco-Betancourt C, Grivel K, Richter K, Schiff C (Mar 2004). "Binding of free immunoglobulin light chains to VpreB3 inhibits their maturation and secretion in chicken B cells". J Biol Chem. 279 (11): 10228–36. doi:10.1074/jbc.M312169-A200. PMID 14670953.
8. "Entrez Gene: VPREB3 pre-B lymphocyte gene 3".

Further reading

• Melchers F, Karasuyama H, Haasner D, et al. (1993). "The surrogate light chain in B-cell development". Immunol. Today. 14 (2): 60–8. doi:10.1016/0167-5699(93)90060-X. PMID 8166770.
• Ohnishi K, Takemori T (1994). "Molecular components and assembly of mu.surrogate light chain complexes in pre-B cell lines". J. Biol. Chem. 269 (45): 28347–53. PMID 7961773.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
• Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMC 545604. PMID 15461802.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Rangel R, McKeller MR, Sims-Mourtada JC, et al. (2005). "Assembly of the kappa preB receptor requires a V kappa-like protein encoded by a germline transcript". J. Biol. Chem. 280 (18): 17807–14. doi:10.1074/jbc.M409479200. PMID 15757909.