VPS36

Vacuolar protein-sorting-associated protein 36 is a protein that in humans is encoded by the VPS36 gene.[5][6][7]

VPS36
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2HTH, 2ZME, 3CUQ
Identifiers
Aliases	VPS36, C13orf9, EAP45, CGI-145, vacuolar protein sorting 36 homolog
External IDs	OMIM: 610903 MGI: 1917410 HomoloGene: 9374 GeneCards: VPS36
Gene location (Human) Chr. Chromosome 13 (human)[1] Band 13q14.3 Start 52,412,602 bp[1] End 52,450,634 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8|8 A2 Start 22,192,809 bp[2] End 22,220,843 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • phosphatidylinositol-3-phosphate binding • protein C-terminus binding • ubiquitin binding • GO:0001948 protein binding • lipid binding Cellular component • cytoplasm • cytosol • late endosome • membrane • late endosome membrane • lysosome • extracellular exosome • cell nucleus • endosome • ESCRT II complex Biological process • regulation of transcription, DNA-templated • multivesicular body assembly • transcription, DNA-templated • endosomal transport • protein transport • protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway • macroautophagy • transport • endosome transport via multivesicular body sorting pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	51028	70160
Ensembl	ENSG00000136100	ENSMUSG00000031479
UniProt	Q86VN1	Q91XD6
RefSeq (mRNA)	NM_016075 NM_001282168 NM_001282169	NM_027338 NM_001368379
RefSeq (protein)	NP_001269097 NP_001269098 NP_057159	NP_081614 NP_001355308
Location (UCSC)	Chr 13: 52.41 – 52.45 Mb	Chr 8: 22.19 – 22.22 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000136100 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000031479 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Kamura T, Burian D, Khalili H, Schmidt SL, Sato S, Liu WJ, Conrad MN, Conaway RC, Conaway JW, Shilatifard A (May 2001). "Cloning and characterization of ELL-associated proteins EAP45 and EAP20. a role for yeast EAP-like proteins in regulation of gene expression by glucose". J Biol Chem. 276 (19): 16528–33. doi:10.1074/jbc.M010142200. PMID 11278625.
6. Slagsvold T, Aasland R, Hirano S, Bache KG, Raiborg C, Trambaiolo D, Wakatsuki S, Stenmark H (May 2005). "Eap45 in mammalian ESCRT-II binds ubiquitin via a phosphoinositide-interacting GLUE domain". J Biol Chem. 280 (20): 19600–6. doi:10.1074/jbc.M501510200. PMID 15755741.
7. "Entrez Gene: VPS36 vacuolar protein sorting 36 homolog (S. cerevisiae)".

Further reading

• Lai CH, Chou CY, Ch'ang LY, et al. (2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics". Genome Res. 10 (5): 703–13. doi:10.1101/gr.10.5.703. PMC 310876. PMID 10810093.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• von Schwedler UK, Stuchell M, Müller B, et al. (2003). "The protein network of HIV budding". Cell. 114 (6): 701–13. doi:10.1016/S0092-8674(03)00714-1. PMID 14505570.
• Martin-Serrano J, Yarovoy A, Perez-Caballero D, et al. (2003). "Divergent retroviral late-budding domains recruit vacuolar protein sorting factors by using alternative adaptor proteins". Proc. Natl. Acad. Sci. U.S.A. 100 (21): 12414–9. doi:10.1073/pnas.2133846100. PMC 218772. PMID 14519844.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Dunham A, Matthews LH, Burton J, et al. (2004). "The DNA sequence and analysis of human chromosome 13". Nature. 428 (6982): 522–8. doi:10.1038/nature02379. PMC 2665288. PMID 15057823.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Bowers K, Piper SC, Edeling MA, et al. (2006). "Degradation of endocytosed epidermal growth factor and virally ubiquitinated major histocompatibility complex class I is independent of mammalian ESCRTII". J. Biol. Chem. 281 (8): 5094–105. doi:10.1074/jbc.M508632200. PMID 16371348.
• Alam SL, Langelier C, Whitby FG, et al. (2007). "Structural basis for ubiquitin recognition by the human ESCRT-II EAP45 GLUE domain". Nat. Struct. Mol. Biol. 13 (11): 1029–30. doi:10.1038/nsmb1160. PMID 17057716.