VPS39

hVamp6/Vps39-like protein is a protein that in humans is encoded by the VPS39 gene.[5][6]

VPS39
Identifiers
Aliases	VPS39, TLP, VAM6, hVam6p, HOPS complex subunit, VPS39 subunit of HOPS complex
External IDs	OMIM: 612188 MGI: 2443189 HomoloGene: 41025 GeneCards: VPS39
Gene location (Human) Chr. Chromosome 15 (human)[1] Band 15q15.1 Start 42,158,701 bp[1] End 42,208,316 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 E5 Start 120,316,461 bp[2] End 120,353,137 bp[2]
RNA expression pattern More reference expression data
Orthologs
Species	Human	Mouse
Entrez	23339	269338
Ensembl	ENSG00000166887	ENSMUSG00000027291
UniProt	Q96JC1	Q8R5L3
RefSeq (mRNA)	NM_001301138 NM_015289	NM_147153 NM_178851 NM_001363053 NM_001363054
RefSeq (protein)	NP_001288067 NP_056104	NP_671495 NP_849182 NP_001349982 NP_001349983
Location (UCSC)	Chr 15: 42.16 – 42.21 Mb	Chr 2: 120.32 – 120.35 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a protein that may promote clustering and fusion of late endosomes and lysosomes. The protein may also act as an adaptor protein that modulates the transforming growth factor-beta response by coupling the transforming growth factor-beta receptor complex to the Smad pathway.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000166887 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000027291 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Caplan S, Hartnell LM, Aguilar RC, Naslavsky N, Bonifacino JS (Jul 2001). "Human Vam6p promotes lysosome clustering and fusion in vivo". J Cell Biol. 154 (1): 109–122. doi:10.1083/jcb.200102142. PMC 2196876. PMID 11448994.
6. "Entrez Gene: VPS39 vacuolar protein sorting 39 homolog (S. cerevisiae)".

Further reading

• Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
• Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (5): 277–286. doi:10.1093/dnares/5.5.277. PMID 9872452.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–1795. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–435. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Felici A, Wurthner JU, Parks WT, et al. (2003). "TLP, a novel modulator of TGF-beta signaling, has opposite effects on Smad2- and Smad3-dependent signaling". EMBO J. 22 (17): 4465–4477. doi:10.1093/emboj/cdg428. PMC 202370. PMID 12941698.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–2144. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–1178. doi:10.1038/nature04209. PMID 16189514.
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–D418. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.