VTI1A

Vesicle transport through interaction with t-SNAREs homolog 1A is a protein that in humans is encoded by the VTI1A gene.[5][6]

VTI1A
Identifiers
Aliases	VTI1A, MMDS3, MVti1, VTI1RP2, Vti1-rp2, vesicle transport through interaction with t-SNAREs 1A
External IDs	OMIM: 614316 MGI: 1855699 HomoloGene: 39963 GeneCards: VTI1A
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10q25.2 Start 112,446,998 bp[1] End 112,818,744 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19|19 D2 Start 55,316,295 bp[2] End 55,627,309 bp[2]
Gene ontology Molecular function • SNAP receptor activity • GO:0001948 protein binding • SNARE binding Cellular component • integral component of membrane • endosome • Golgi apparatus • membrane • synaptic vesicle • autophagosome • neuronal cell body • SNARE complex • perinuclear region of cytoplasm • neuron projection terminus • cytoplasmic vesicle • clathrin-coated vesicle • trans-Golgi network membrane • ER to Golgi transport vesicle membrane • cytosol • Golgi membrane • late endosome membrane • endoplasmic reticulum membrane • intracellular membrane-bounded organelle Biological process • voluntary musculoskeletal movement • autophagy • retrograde transport, endosome to Golgi • protein transport • intracellular protein transport • Golgi ribbon formation • vesicle-mediated transport • Golgi to vacuole transport • vesicle fusion with Golgi apparatus • intra-Golgi vesicle-mediated transport • ER to Golgi vesicle-mediated transport • protein targeting to vacuole Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	143187	53611
Ensembl	ENSG00000151532	ENSMUSG00000024983
UniProt	Q96AJ9	O89116
RefSeq (mRNA)	NM_145206 NM_001318203 NM_001318205 NM_001365710 NM_001365711 NM_001365712 NM_001365713 NM_001365714	NM_001293685 NM_001293686 NM_016862 NM_001360431 NM_001360432
RefSeq (protein)	NP_001305132 NP_001305134 NP_660207 NP_001352639 NP_001352640 NP_001352641 NP_001352642 NP_001352643	NP_001280614 NP_001280615 NP_058558 NP_001347360 NP_001347361
Location (UCSC)	Chr 10: 112.45 – 112.82 Mb	Chr 19: 55.32 – 55.63 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

The protein encoded by the VTI1A gene is a target-SNARE (t-SNARE) protein which is located in the membranes of target vesicle compartments.

References

1. GRCh38: Ensembl release 89: ENSG00000151532 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000024983 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: vesicle transport through interaction with t-SNAREs homolog 1A (yeast)".
6. Fischer von Mollard G, Stevens TH (January 1998). "A human homolog can functionally replace the yeast vesicle-associated SNARE Vti1p in two vesicle transport pathways". J. Biol. Chem. 273 (5): 2624–30. doi:10.1074/jbc.273.5.2624. PMID 9446565.

Further reading

• Luke MM, O'Meara ES, Rowland CM, et al. (2009). "Gene Variants Associated With Ischemic Stroke: The Cardiovascular Health Study". Stroke. 40 (2): 363–8. doi:10.1161/STROKEAHA.108.521328. PMC 2881155. PMID 19023099.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Grupe A, Li Y, Rowland C, et al. (2006). "A Scan of Chromosome 10 Identifies a Novel Locus Showing Strong Association with Late-Onset Alzheimer Disease". Am. J. Hum. Genet. 78 (1): 78–88. doi:10.1086/498851. PMC 1380225. PMID 16385451.
• Mallard F, Tang BL, Galli T, et al. (2002). "Early/recycling endosomes-to-TGN transport involves two SNARE complexes and a Rab6 isoform". J. Cell Biol. 156 (4): 653–64. doi:10.1083/jcb.200110081. PMC 2174079. PMID 11839770.
• Shiffman D, O'Meara ES, Bare LA, et al. (2008). "Association of Gene Variants with Incident Myocardial Infarction in the Cardiovascular Health Study". Arterioscler. Thromb. Vasc. Biol. 28 (1): 173–9. doi:10.1161/ATVBAHA.107.153981. PMC 2636623. PMID 17975119.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Flowerdew SE, Burgoyne RD (2009). "A VAMP7/Vti1a SNARE complex distinguishes a non-conventional traffic route to the cell surface used by KChIP1 and Kv4 potassium channels". Biochem. J. 418 (3): 529–40. doi:10.1042/BJ20081736. PMC 2650881. PMID 19138172.
• Tai G, Lu L, Wang TL, et al. (2004). "Participation of the Syntaxin 5/Ykt6/GS28/GS15 SNARE Complex in Transport from the Early/Recycling Endosome to the Trans-Golgi Network". Mol. Biol. Cell. 15 (9): 4011–22. doi:10.1091/mbc.E03-12-0876. PMC 515336. PMID 15215310.
• Antonin W, Holroyd C, Fasshauer D, et al. (2000). "A SNARE complex mediating fusion of late endosomes defines conserved properties of SNARE structure and function". EMBO J. 19 (23): 6453–64. doi:10.1093/emboj/19.23.6453. PMC 305878. PMID 11101518.