WARS2

Tryptophanyl-tRNA synthetase, mitochondrial is an enzyme that in humans is encoded by the WARS2 gene.[5][6][7]

WARS2
Identifiers
Aliases	WARS2, TrpRS, tryptophanyl tRNA synthetase 2, mitochondrial, NEMMLAS, mtTrpRS
External IDs	OMIM: 604733 MGI: 1917810 HomoloGene: 5673 GeneCards: WARS2
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p12 Start 119,031,216 bp[1] End 119,140,671 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 F2.2 Start 99,141,068 bp[2] End 99,239,186 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • aminoacyl-tRNA ligase activity • nucleotide binding • ligase activity • ATP binding • tryptophan-tRNA ligase activity Cellular component • cytoplasm • mitochondrion • cell membrane • mitochondrial matrix Biological process • vasculogenesis • tryptophanyl-tRNA aminoacylation • tRNA aminoacylation for protein translation • protein biosynthesis • mitochondrial tryptophanyl-tRNA aminoacylation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10352	70560
Ensembl	ENSG00000116874	ENSMUSG00000004233
UniProt	Q9UGM6	Q9CYK1
RefSeq (mRNA)	NM_015836 NM_201263 NM_001378226 NM_001378227 NM_001378228 NM_001378229 NM_001378230 NM_001378231	NM_027462
RefSeq (protein)	NP_056651 NP_957715 NP_001365155 NP_001365156 NP_001365157 NP_001365158 NP_001365159 NP_001365160	NP_081738
Location (UCSC)	Chr 1: 119.03 – 119.14 Mb	Chr 3: 99.14 – 99.24 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Two forms of tryptophanyl-tRNA synthetase exist, a cytoplasmic form, named WARS, and a mitochondrial form, named WARS2. This gene encodes the mitochondrial tryptophanyl-tRNA synthetase. Two alternative transcripts encoding different isoforms have been described.[7]

References

1. GRCh38: Ensembl release 89: ENSG00000116874 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000004233 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Martinez-Dominguez MT, Justesen J, Kruse TA, Hansen LL (Mar 1999). "Assignment of the human mitochondrial tryptophanyl-tRNA synthetase (WARS2) to 1p13.3→p13.1 by radiation hybrid mapping". Cytogenet Cell Genet. 83 (3–4): 249–50. doi:10.1159/000015196. PMID 10072595. S2CID 28931531.
6. Jorgensen R, Søgaard TM, Rossing AB, Martensen PM, Justesen J (Jul 2000). "Identification and characterization of human mitochondrial tryptophanyl-tRNA synthetase". J Biol Chem. 275 (22): 16820–6. doi:10.1074/jbc.275.22.16820. PMID 10828066.
7. "Entrez Gene: WARS2 tryptophanyl tRNA synthetase 2, mitochondrial".

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Liu J, Shue E, Ewalt KL, Schimmel P (2004). "A new gamma-interferon-inducible promoter and splice variants of an anti-angiogenic human tRNA synthetase". Nucleic Acids Res. 32 (2): 719–27. doi:10.1093/nar/gkh240. PMC 373357. PMID 14757836.
• Oh JH, Yang JO, Hahn Y, Kim MR, Byun SS, Jeon YJ, Kim JM, Song KS, Noh SM, Kim S, Yoo HS, Kim YS, Kim NS (2006). "Transcriptome analysis of human gastric cancer". Mamm. Genome. 16 (12): 942–54. doi:10.1007/s00335-005-0075-2. PMID 16341674. S2CID 69278.
• Guo LT, Chen XL, Zhao BT, Shi Y, Li W, Xue H, Jin YX (2007). "Human tryptophanyl-tRNA synthetase is switched to a tRNA-dependent mode for tryptophan activation by mutations at V85 and I311". Nucleic Acids Res. 35 (17): 5934–43. doi:10.1093/nar/gkm633. PMC 2034488. PMID 17726052.

External links

• WARS2 human gene location in the UCSC Genome Browser.
• WARS2 human gene details in the UCSC Genome Browser.