WDR1

WD repeat-containing protein 1 is a protein that in humans is encoded by the WDR1 gene.[5][6]

WDR1
Identifiers
Aliases	WDR1, AIP1, HEL-S-52, NORI-1, WD repeat domain 1
External IDs	OMIM: 604734 MGI: 1337100 HomoloGene: 6628 GeneCards: WDR1
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4p16.1 Start 10,074,339 bp[1] End 10,116,949 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5 B3|5 20.63 cM Start 38,526,813 bp[2] End 38,563,221 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • actin binding • actin filament binding Cellular component • extracellular region • myelin • podosomes • cell junction • cell projection • extracellular exosome • cytoskeleton • actin filament • intercellular junction • cytoplasm • cytosol • cortical actin cytoskeleton • cell membrane Biological process • platelet degranulation • sensory perception of sound • actin cytoskeleton organization • regulation of ventricular cardiac muscle cell membrane repolarization • regulation of oligodendrocyte differentiation • maintenance of epithelial cell apical/basal polarity • apical junction assembly • regulation of actin filament depolymerization • neutrophil mediated immunity • regulation of cell shape • actin filament fragmentation • platelet formation • positive regulation of actin filament depolymerization • cortical cytoskeleton organization • locomotion • establishment of planar polarity of follicular epithelium • sarcomere organization • neutrophil migration • actin filament depolymerization Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	9948	22388
Ensembl	ENSG00000071127	ENSMUSG00000005103
UniProt	O75083	O88342
RefSeq (mRNA)	NM_005112 NM_017491	NM_011715
RefSeq (protein)	NP_005103 NP_059830	NP_035845
Location (UCSC)	Chr 4: 10.07 – 10.12 Mb	Chr 5: 38.53 – 38.56 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a protein containing 9 WD repeats. WD repeats are approximately 30- to 40-amino acid domains containing several conserved residues, mostly including a trp-asp at the C-terminal end. WD domains are involved in protein-protein interactions. The encoded protein may help induce the disassembly of actin filaments. Two transcript variants encoding different isoforms have been found for this gene.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000071127 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000005103 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Adler HJ, Winnicki RS, Gong TW, Lomax MI (May 1999). "A gene upregulated in the acoustically damaged chick basilar papilla encodes a novel WD40 repeat protein". Genomics. 56 (1): 59–69. doi:10.1006/geno.1998.5672. PMID 10036186.
6. "Entrez Gene: WDR1 WD repeat domain 1".

Further reading

• Dawson SJ, White LA (1992). "Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin". J. Infect. 24 (3): 317–20. doi:10.1016/S0163-4453(05)80037-4. PMID 1602151.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Rodal AA, Tetreault JW, Lappalainen P, et al. (1999). "Aip1p interacts with cofilin to disassemble actin filaments". J. Cell Biol. 145 (6): 1251–64. doi:10.1083/jcb.145.6.1251. PMC 2133144. PMID 10366597.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801. S2CID 23783563.
• Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455. S2CID 7200157.
• Fujibuchi T, Abe Y, Takeuchi T, et al. (2005). "AIP1/WDR1 supports mitotic cell rounding". Biochem. Biophys. Res. Commun. 327 (1): 268–75. doi:10.1016/j.bbrc.2004.11.156. PMID 15629458.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.