WDR33

WD repeat-containing protein 33 is a protein that in humans is encoded by the WDR33 gene.[5][6]

WDR33
Identifiers
Aliases	WDR33, NET14, WDC146, WD repeat domain 33
External IDs	OMIM: 618082 MGI: 1921570 HomoloGene: 56807 GeneCards: WDR33
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q14.3 Start 127,701,027 bp[1] End 127,811,187 bp[1]
Gene location (Mouse) Chr. Chromosome 18 (mouse)[2] Band 18|18 B1 Start 31,804,090 bp[2] End 31,907,397 bp[2]
Gene ontology Molecular function • RNA binding Cellular component • mRNA cleavage and polyadenylation specificity factor complex • collagen • cell nucleus • fibrillar center • nucleoplasm Biological process • mRNA processing • mRNA cleavage • postreplication repair • spermatogenesis • mRNA splicing, via spliceosome • termination of RNA polymerase II transcription • mRNA export from nucleus • mRNA 3'-end processing • mRNA polyadenylation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	55339	74320
Ensembl	ENSG00000136709	ENSMUSG00000024400
UniProt	Q9C0J8	Q8K4P0
RefSeq (mRNA)	NM_001006622 NM_001006623 NM_018383	NM_001170966 NM_001170967 NM_001170970 NM_028866
RefSeq (protein)	NP_001006623 NP_001006624 NP_060853	NP_001164437 NP_001164438 NP_001164441 NP_083142
Location (UCSC)	Chr 2: 127.7 – 127.81 Mb	Chr 18: 31.8 – 31.91 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This gene is highly expressed in testis and the protein is localized to the nucleus. This gene may play important roles in the mechanisms of cytodifferentiation and/or DNA recombination. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000136709 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000024400 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Ito S, Sakai A, Nomura T, Miki Y, Ouchida M, Sasaki J, Shimizu K (Feb 2001). "A novel WD40 repeat protein, WDC146, highly expressed during spermatogenesis in a stage-specific manner". Biochem Biophys Res Commun. 280 (3): 656–63. doi:10.1006/bbrc.2000.4163. PMID 11162572.
6. "Entrez Gene: WDR33 WD repeat domain 33".

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Hillier LD, Lennon G, Becker M, et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags". Genome Res. 6 (9): 807–28. doi:10.1101/gr.6.9.807. PMID 8889549.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715): 1621–5. doi:10.1126/science.1105776. PMID 15761153. S2CID 39457788.
• Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070. S2CID 8235923.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.