WDR36

WD repeat-containing protein 36 is a protein that in humans is encoded by the WDR36 gene.[5][6][7]

WDR36
Identifiers
Aliases	WDR36, GLC1G, TA-WDRP, TAWDRP, UTP21, WD repeat domain 36
External IDs	OMIM: 609669 MGI: 1917819 HomoloGene: 6536 GeneCards: WDR36
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q22.1 Start 111,091,716 bp[1] End 111,130,502 bp[1]
Gene location (Mouse) Chr. Chromosome 18 (mouse)[2] Band 18|18 B1 Start 32,837,225 bp[2] End 32,867,594 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • RNA binding Cellular component • nucleolus • cell nucleus • nucleoplasm • small-subunit processome • Pwp2p-containing subcomplex of 90S preribosome Biological process • retina homeostasis • regulation of axon extension • ribosome biogenesis • response to stimulus • visual perception • rRNA processing • biological process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	134430	225348
Ensembl	ENSG00000134987	ENSMUSG00000038299
UniProt	Q8NI36	n/a
RefSeq (mRNA)	NM_139281	NM_001110015 NM_001110016 NM_144863
RefSeq (protein)	NP_644810	n/a
Location (UCSC)	Chr 5: 111.09 – 111.13 Mb	Chr 18: 32.84 – 32.87 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Mutations in this gene have been associated with adult-onset primary open-angle glaucoma (POAG).[7]

References

1. GRCh38: Ensembl release 89: ENSG00000134987 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000038299 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Bernstein KA, Gallagher JE, Mitchell BM, Granneman S, Baserga SJ (Dec 2004). "The small-subunit processome is a ribosome assembly intermediate". Eukaryot Cell. 3 (6): 1619–26. doi:10.1128/EC.3.6.1619-1626.2004. PMC 539036. PMID 15590835.
6. Monemi S, Spaeth G, DaSilva A, Popinchalk S, Ilitchev E, Liebmann J, Ritch R, Heon E, Crick RP, Child A, Sarfarazi M (Mar 2005). "Identification of a novel adult-onset primary open-angle glaucoma (POAG) gene on 5q22.1". Hum Mol Genet. 14 (6): 725–33. doi:10.1093/hmg/ddi068. PMID 15677485.
7. "Entrez Gene: WDR36 WD repeat domain 36".

Further reading

• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Mao M, Biery MC, Kobayashi SV, et al. (2005). "T lymphocyte activation gene identification by coregulated expression on DNA microarrays". Genomics. 83 (6): 989–99. doi:10.1016/j.ygeno.2003.12.019. PMID 15177553.
• Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.
• Pang CP, Fan BJ, Canlas O, et al. (2006). "A genome-wide scan maps a novel juvenile-onset primary open angle glaucoma locus to chromosome 5q". Mol. Vis. 12: 85–92. PMID 16518310.
• Hauser MA, Allingham RR, Linkroum K, et al. (2006). "Distribution of WDR36 DNA sequence variants in patients with primary open-angle glaucoma". Invest. Ophthalmol. Vis. Sci. 47 (6): 2542–6. doi:10.1167/iovs.05-1476. PMID 16723468.
• Hewitt AW, Dimasi DP, Mackey DA, Craig JE (2006). "A Glaucoma Case-control Study of the WDR36 Gene D658G sequence variant". Am. J. Ophthalmol. 142 (2): 324–5. doi:10.1016/j.ajo.2006.02.041. PMID 16876519.
• Kramer PL, Samples JR, Monemi S, et al. (2006). "The role of the WDR36 gene on chromosome 5q22.1 in a large family with primary open-angle glaucoma mapped to this region". Arch. Ophthalmol. 124 (9): 1328–31. doi:10.1001/archopht.124.9.1328. PMID 16966629.
• Weisschuh N, Wolf C, Wissinger B, Gramer E (2007). "Variations in the WDR36 gene in German patients with normal tension glaucoma". Mol. Vis. 13: 724–9. PMC 2765470. PMID 17563723.
• Miyazawa A, Fuse N, Mengkegale M, et al. (2007). "Association between primary open-angle glaucoma and WDR36 DNA sequence variants in Japanese". Mol. Vis. 13: 1912–9. PMID 17960130.