WDR83

WD repeat domain 83 is a protein that in humans is encoded by the WDR83 gene. [5]

WDR83
Identifiers
Aliases	WDR83, MORG1, WD repeat domain 83
External IDs	OMIM: 616850 MGI: 1915086 HomoloGene: 12194 GeneCards: WDR83
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19p13.13 Start 12,666,802 bp[1] End 12,675,832 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8|8 C3 Start 85,075,035 bp[2] End 85,081,306 bp[2]
Gene ontology Molecular function • GO:0001948 protein binding Cellular component • cytoplasm • catalytic step 2 spliceosome • spliceosomal complex • endosome membrane • cell nucleus Biological process • mRNA splicing, via spliceosome • RNA splicing, via transesterification reactions • mRNA processing • MAPK cascade • RNA splicing Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	84292	67836
Ensembl	ENSG00000123154	ENSMUSG00000005150
UniProt	Q9BRX9	Q9DAJ4
RefSeq (mRNA)	NM_001099737 NM_032332	NM_026399
RefSeq (protein)	NP_001093207 NP_115708	NP_080675
Location (UCSC)	Chr 19: 12.67 – 12.68 Mb	Chr 8: 85.08 – 85.08 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene encodes a member of the WD-40 protein family. The protein is proposed to function as a molecular scaffold for various multimeric protein complexes. The protein associates with several components of the extracellular signal-regulated kinase (ERK) pathway, and promotes ERK activity in response to serum or other signals. The protein also interacts with egl nine homolog 3 (EGLN3, also known as PHD3) and regulates expression of hypoxia-inducible factor 1, and has been purified as part of the spliceosome. Alternative splicing results in multiple transcript variants.

References

1. GRCh38: Ensembl release 89: ENSG00000123154 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000005150 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: WD repeat domain 83". Retrieved 2017-06-15.

Further reading

• Jurica MS, Licklider LJ, Gygi SR, Grigorieff N, Moore MJ (2002). "Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis". RNA. 8 (4): 426–39. doi:10.1017/s1355838202021088. PMC 1370266. PMID 11991638.
• Vomastek T, Schaeffer HJ, Tarcsafalvi A, Smolkin ME, Bissonette EA, Weber MJ (2004). "Modular construction of a signaling scaffold: MORG1 interacts with components of the ERK cascade and links ERK signaling to specific agonists". Proc. Natl. Acad. Sci. U.S.A. 101 (18): 6981–6. Bibcode:2004PNAS..101.6981V. doi:10.1073/pnas.0305894101. PMC 406452. PMID 15118098.
• Hopfer U, Hopfer H, Jablonski K, Stahl RA, Wolf G (2006). "The novel WD-repeat protein Morg1 acts as a molecular scaffold for hypoxia-inducible factor prolyl hydroxylase 3 (PHD3)". J. Biol. Chem. 281 (13): 8645–55. doi:10.1074/jbc.M513751200. PMID 16407229.
• Haase D, Keiner S, Mawrin C, Wolf G (2009). "Reduced Morg1 expression in ischemic human brain". Neurosci. Lett. 455 (1): 46–50. doi:10.1016/j.neulet.2009.03.048. PMID 19429104. S2CID 27095825.
• Su WY, Li JT, Cui Y, Hong J, Du W, Wang YC, Lin YW, Xiong H, Wang JL, Kong X, Gao QY, Wei LP, Fang JY (2012). "Bidirectional regulation between WDR83 and its natural antisense transcript DHPS in gastric cancer". Cell Res. 22 (9): 1374–89. doi:10.1038/cr.2012.57. PMC 3434345. PMID 22491477.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.